Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998681857> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1998681857 endingPage "10376" @default.
- W1998681857 startingPage "10371" @default.
- W1998681857 abstract "The cellular location and substrate specificity of the catalytic subunit (C) of protein phosphatase 2A (PP2A) depend on its interaction with A and B subunits. The distribution of epitope-tagged wild-type or mutated C subunits was studied by transient expression in COS-7 cells. Wild-type tagged C expressed at low levels formed ABC trimer and AC dimer like the endogenous C. Single mutations of C at the site of phosphorylation (Y307F) or carboxymethylation (L309Q) resulted in recovery of only AC dimer. Double mutation of both residues resulted in association of C with α4 protein (α4), a novel subunit of PP2A, instead of with A and B subunits. Thus, the distribution of C between ABC trimer, AC dimer, and α4C complexes can be affected by modifications of the C-terminal residues. The α4 protein is a homologue of the yeast Tap42 protein that functions downstream of the TOR protein to regulate protein synthesis. Transient overexpression of FLAG-α4 resulted in increased dephosphorylation of elongation factor 2, but had no effect on phosphorylation of either p70S6 kinase or PHAS-I (eIF4E-BP). Signals that affect phosphorylation or methylation of the C subunit of PP2A may promote subunit exchange and direct phosphatase activity to specific intracellular substrates." @default.
- W1998681857 created "2016-06-24" @default.
- W1998681857 creator A5028829439 @default.
- W1998681857 creator A5032456571 @default.
- W1998681857 creator A5046658997 @default.
- W1998681857 creator A5074981380 @default.
- W1998681857 date "1999-07-22" @default.
- W1998681857 modified "2023-09-23" @default.
- W1998681857 title "Mutation of Tyr307 and Leu309 in the Protein Phosphatase 2A Catalytic Subunit Favors Association with the α4 Subunit Which Promotes Dephosphorylation of Elongation Factor-2" @default.
- W1998681857 cites W141764926 @default.
- W1998681857 cites W1499558028 @default.
- W1998681857 cites W1512809531 @default.
- W1998681857 cites W1598704961 @default.
- W1998681857 cites W1749755354 @default.
- W1998681857 cites W1853822177 @default.
- W1998681857 cites W2013542464 @default.
- W1998681857 cites W2026508325 @default.
- W1998681857 cites W2057593147 @default.
- W1998681857 cites W2072401667 @default.
- W1998681857 cites W2099577277 @default.
- W1998681857 cites W2137221055 @default.
- W1998681857 cites W2340946024 @default.
- W1998681857 cites W4300580226 @default.
- W1998681857 doi "https://doi.org/10.1021/bi990902g" @default.
- W1998681857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10441131" @default.
- W1998681857 hasPublicationYear "1999" @default.
- W1998681857 type Work @default.
- W1998681857 sameAs 1998681857 @default.
- W1998681857 citedByCount "86" @default.
- W1998681857 countsByYear W19986818572012 @default.
- W1998681857 countsByYear W19986818572013 @default.
- W1998681857 countsByYear W19986818572014 @default.
- W1998681857 countsByYear W19986818572015 @default.
- W1998681857 countsByYear W19986818572016 @default.
- W1998681857 countsByYear W19986818572018 @default.
- W1998681857 countsByYear W19986818572019 @default.
- W1998681857 countsByYear W19986818572020 @default.
- W1998681857 countsByYear W19986818572022 @default.
- W1998681857 crossrefType "journal-article" @default.
- W1998681857 hasAuthorship W1998681857A5028829439 @default.
- W1998681857 hasAuthorship W1998681857A5032456571 @default.
- W1998681857 hasAuthorship W1998681857A5046658997 @default.
- W1998681857 hasAuthorship W1998681857A5074981380 @default.
- W1998681857 hasConcept C104292427 @default.
- W1998681857 hasConcept C104317684 @default.
- W1998681857 hasConcept C11960822 @default.
- W1998681857 hasConcept C153911025 @default.
- W1998681857 hasConcept C178666793 @default.
- W1998681857 hasConcept C178790620 @default.
- W1998681857 hasConcept C181912034 @default.
- W1998681857 hasConcept C185592680 @default.
- W1998681857 hasConcept C2776403692 @default.
- W1998681857 hasConcept C2779546866 @default.
- W1998681857 hasConcept C389152 @default.
- W1998681857 hasConcept C55493867 @default.
- W1998681857 hasConcept C86803240 @default.
- W1998681857 hasConcept C95444343 @default.
- W1998681857 hasConcept C97029542 @default.
- W1998681857 hasConceptScore W1998681857C104292427 @default.
- W1998681857 hasConceptScore W1998681857C104317684 @default.
- W1998681857 hasConceptScore W1998681857C11960822 @default.
- W1998681857 hasConceptScore W1998681857C153911025 @default.
- W1998681857 hasConceptScore W1998681857C178666793 @default.
- W1998681857 hasConceptScore W1998681857C178790620 @default.
- W1998681857 hasConceptScore W1998681857C181912034 @default.
- W1998681857 hasConceptScore W1998681857C185592680 @default.
- W1998681857 hasConceptScore W1998681857C2776403692 @default.
- W1998681857 hasConceptScore W1998681857C2779546866 @default.
- W1998681857 hasConceptScore W1998681857C389152 @default.
- W1998681857 hasConceptScore W1998681857C55493867 @default.
- W1998681857 hasConceptScore W1998681857C86803240 @default.
- W1998681857 hasConceptScore W1998681857C95444343 @default.
- W1998681857 hasConceptScore W1998681857C97029542 @default.
- W1998681857 hasIssue "32" @default.
- W1998681857 hasLocation W19986818571 @default.
- W1998681857 hasLocation W19986818572 @default.
- W1998681857 hasOpenAccess W1998681857 @default.
- W1998681857 hasPrimaryLocation W19986818571 @default.
- W1998681857 hasRelatedWork W1966412214 @default.
- W1998681857 hasRelatedWork W1998681857 @default.
- W1998681857 hasRelatedWork W2015862623 @default.
- W1998681857 hasRelatedWork W2021576764 @default.
- W1998681857 hasRelatedWork W2028727657 @default.
- W1998681857 hasRelatedWork W2035246661 @default.
- W1998681857 hasRelatedWork W2044365168 @default.
- W1998681857 hasRelatedWork W2046487040 @default.
- W1998681857 hasRelatedWork W2064221515 @default.
- W1998681857 hasRelatedWork W3117546060 @default.
- W1998681857 hasVolume "38" @default.
- W1998681857 isParatext "false" @default.
- W1998681857 isRetracted "false" @default.
- W1998681857 magId "1998681857" @default.
- W1998681857 workType "article" @default.