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• W1998688081 abstract "To investigate the biochemical markers such as nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH), indicators of the oxidative status of the follicle, to predict the outcome of in vitro fertilization.Follicular aspirates of dominant follicles were collected during oocyte retrieval. Biochemical analyses of NO, MDA and GSH were performed on all aspirates.When the successful and unsuccessful pregnancy groups were compared in terms of NO, MDA and GSH, follicular fluid MDA was significantly higher (p=0.001) and follicular fluid NO level was significantly lower (p=0.039) in the pregnant group. Correlation analysis between oxidative stress and IVF parameters showed that MDA had a positive weak correlation with the number of grade 1 embryos (r=0.271, p=0.033) and fertilization rate (r=0.263, p=0.039). ROC curve analysis found that malondialdehyde has an area under the curve of 0.74 and can predict pregnancy with high sensitivity.As malondialdehyde was significantly different in pregnant and non-pregnant women and had a good sensitivity profile in predicting pregnancy, it may be considered a marker for predicting IVF success.Folikül oksidatif durumunun belirteci olan nitrik oksit (NO), malondialdehit (MDA) ve redükte glutatyon (GSH) gibi kimyasal belirteçlerin in vitro fertilizasyon başarısına etkisinin araştırılması.Oosit toplama sırasında dominant foliküllerin aspire edilen sıvıları toplandı. Tüm aspire edilen sıvılarda biyokimyasal analiz ile NO, MDA ve GSH seviyelerine bakıldı.Gebelikle sonuçlanan ve gebe kalamayan olguların NO, MDA and GSH seviyeleri karşılaştırıldığında, folikül sıvısı MDA seviyesi gebe kalanlarda anlamlı olarak yüksek bulunurken (p=0.001), NO seviyesi ise gebe kalanlarda anlamlı olarak düşük bulundu (p=0.039). Oksidatif stres ve in vitro fertilizasyon parametreleri arasında korelasyon analizi yapıldığında, MDA ile grade 1 embriyo sayısı arasında (r=0.271, p=0.033) ve fertilizasyon oranı arasında (r=0.263, p=0.039) zayıf pozitif bir korrelasyon bulundu. ROC eğrisi analizinde MDA’nın çizgi altında kalan alanı 0.74 hesaplanarak gebe kalan olguları öngörmede yüksek bir duyarlılığı olduğu bulundu.Malondialdehit gebe kalan olguların follikül sıvılarında gebe kalamayanlardan anlamlı olarak yüksek bulunmasının yanı sıra, gebeliği öngörmede iyi bir duyarlılığa sahipti ve IVF olgularında gebeliği öngörmede bir belirteç olarak kullanılabilir." @default.
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• W1998688081 date "2013-09-10" @default.
• W1998688081 modified "2023-10-17" @default.
• W1998688081 title "Effect of Follicular Fluid NO, MDA and GSH Levels on in vitro Fertilization Outcomes" @default.
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• W1998688081 doi "https://doi.org/10.5152/jtgga.2013.53323" @default.
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