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- W1998695938 endingPage "2598" @default.
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- W1998695938 abstract "Several transcription factors function in the specification and differentiation of the endoderm, including the zinc finger transcription factor GATA4. Despite its essential role in endoderm development, the transcriptional control of the Gata4 gene in the developing endoderm and its derivatives remains incompletely understood. Here, we identify a distal enhancer from the Gata4 gene, which directs expression exclusively to the visceral and definitive endoderm of transgenic mouse embryos. The activity of this enhancer is initially broad within the definitive endoderm but later restricts to developing endoderm-derived tissues, including pancreas, glandular stomach, and duodenum. The activity of this enhancer in vivo is dependent on evolutionarily-conserved HOX- and GATA-binding sites, which are bound by PDX-1 and GATA4, respectively. These studies establish Gata4 as a direct transcriptional target of homeodomain and GATA transcription factors in the endoderm and support a model in which GATA4 functions in the transcriptional network for pancreas formation. Developmental Dynamics 238:2588–2598, 2009. © 2009 Wiley-Liss, Inc." @default.
- W1998695938 created "2016-06-24" @default.
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- W1998695938 date "2009-10-01" @default.
- W1998695938 modified "2023-10-18" @default.
- W1998695938 title "An endoderm-specific transcriptional enhancer from the mouse<i>Gata4</i>gene requires GATA and homeodomain protein-binding sites for function in vivo" @default.
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- W1998695938 doi "https://doi.org/10.1002/dvdy.22091" @default.
- W1998695938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2827249" @default.
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