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- W1998698832 abstract "Although anticholinergic therapies have long been available for treatment of obstructive airway diseases, their use in patients with asthma has remained restricted to the use of short-acting anticholinergics as reliever therapy for some patients, or use in a nebulised form often in combination with a short-acting β-agonist to treat episodes of acute severe asthma. Furthermore, whereas both long-acting anticholinergics, also known as long-acting muscarinic antagonists (LAMA), and long-acting β-adrenergic agonists (LABA) have become established bronchodilator treatments for chronic obstructive pulmonary disease (COPD), only LABAs have been used in patients with asthma. Indeed, LABAs in combination with inhaled corticosteroids have become the recommended treatment for asthma in patients who do not respond to inhaled corticosteroids alone, such as those at step 3 of the Global Initiative for Asthma (GINA) guidelines (ie, those requiring low-dose inhaled corticosteroids and LABA). Combination therapy with inhaled corticosteroids and LABAs, usually inhaled from a single inhaler device, now dominate the asthma treatment market. Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trialsOnce-daily tiotropium add-on to medium-dose inhaled corticosteroids reduces airflow obstruction and improves asthma control in patients with moderate symptomatic asthma. Patterns of response with both tiotropium doses were similar to those of salmeterol, and all active compounds had good safety and tolerability. Tiotropium is a safe and effective bronchodilator, and an alternative to salmeterol in this patient population. Full-Text PDF Bronchodilator reversibility and cardiac considerations with use of tiotropiumIn his Comment,1 Kian Fan Chung provides an overview of our Article2 on the findings from our two 24-week, replicate, randomised active-comparator trials of tiotropium add-on therapy in adult patients with symptomatic asthma despite treatment with medium-dose inhaled corticosteroids. Full-Text PDF" @default.
- W1998698832 created "2016-06-24" @default.
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- W1998698832 date "2015-05-01" @default.
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- W1998698832 title "Tiotropium as an add-on therapy in patients with symptomatic asthma" @default.
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- W1998698832 doi "https://doi.org/10.1016/s2213-2600(15)00039-9" @default.
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