FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998698850> ?p ?o ?g. }

• W1998698850 endingPage "85" @default.
• W1998698850 startingPage "80" @default.
• W1998698850 abstract "Spliced leader RNA transcription is essential for cell viability in trypanosomes. The SL RNA genes are expressed from the only defined RNA polymerase II-dependent promoter identified to date in the trypanosome genome. The SL RNA gene promoter has been shown by in vitro and in vivo analyses to have a tripartite architecture. The upstream most cis-acting element, called PBP-1E, is located between 70 and 60 bp upstream from the transcription start site. This essential element functions along with two downstream elements to direct efficient and proper initiation of transcription. Electrophoretic mobility-shift studies detected a 122-kDa protein, called PBP-1, which interacts with PBP-1E. This protein is the first sequence-specific, double-stranded DNA-binding protein isolated in trypanosomes. Three polypeptides copurify with PBP-1 activity, suggesting that PBP-1 is composed of 57-, 46-, and 36-kDa subunits. We have cloned the genes that encode the 57- and 46-kDa subunits. The 46-kDa protein is a previously uncharacterized protein and may be unique to trypanosomes. Its predicted tertiary structure suggests it binds DNA as part of a complex. The 57-kDa subunit is orthologous to the human small nuclear RNA-activating protein (SNAP)50, which is an essential subunit of the SNAP complex (SNAPc). In human cells, SNAPc binds to the proximal sequence element in both RNA polymerase II- and III-dependent small nuclear RNA gene promoters. These findings identify a surprising link in the transcriptional machinery across a large evolutionary distance in the regulation of small nuclear RNA genes in eukaryotes." @default.
• W1998698850 created "2016-06-24" @default.
• W1998698850 creator A5050217177 @default.
• W1998698850 creator A5061369313 @default.
• W1998698850 date "2002-12-16" @default.
• W1998698850 modified "2023-10-17" @default.
• W1998698850 title "RNA polymerase II-dependent transcription in trypanosomes is associated with a SNAP complex-like transcription factor" @default.
• W1998698850 cites W13855857 @default.
• W1998698850 cites W1547596077 @default.
• W1998698850 cites W1634217411 @default.
• W1998698850 cites W1673194361 @default.
• W1998698850 cites W1865611330 @default.
• W1998698850 cites W1974533240 @default.
• W1998698850 cites W1974906822 @default.
• W1998698850 cites W1977723557 @default.
• W1998698850 cites W1983906951 @default.
• W1998698850 cites W1987109078 @default.
• W1998698850 cites W1990651103 @default.
• W1998698850 cites W1999210446 @default.
• W1998698850 cites W1999587618 @default.
• W1998698850 cites W2033406327 @default.
• W1998698850 cites W2036354940 @default.
• W1998698850 cites W2038081918 @default.
• W1998698850 cites W2050489815 @default.
• W1998698850 cites W2053341447 @default.
• W1998698850 cites W2053934171 @default.
• W1998698850 cites W2055200060 @default.
• W1998698850 cites W2062326792 @default.
• W1998698850 cites W2067358592 @default.
• W1998698850 cites W2068732380 @default.
• W1998698850 cites W2069675793 @default.
• W1998698850 cites W2077718521 @default.
• W1998698850 cites W2084502692 @default.
• W1998698850 cites W2094355872 @default.
• W1998698850 cites W2102565252 @default.
• W1998698850 cites W2103240156 @default.
• W1998698850 cites W2135037886 @default.
• W1998698850 cites W2136711098 @default.
• W1998698850 cites W2163683961 @default.
• W1998698850 cites W2166530501 @default.
• W1998698850 cites W2172519691 @default.
• W1998698850 cites W2194288292 @default.
• W1998698850 cites W2346486326 @default.
• W1998698850 cites W873982878 @default.
• W1998698850 doi "https://doi.org/10.1073/pnas.262609399" @default.
• W1998698850 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140888" @default.
• W1998698850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12486231" @default.
• W1998698850 hasPublicationYear "2002" @default.
• W1998698850 type Work @default.
• W1998698850 sameAs 1998698850 @default.
• W1998698850 citedByCount "49" @default.
• W1998698850 countsByYear W19986988502012 @default.
• W1998698850 countsByYear W19986988502014 @default.
• W1998698850 countsByYear W19986988502016 @default.
• W1998698850 countsByYear W19986988502018 @default.
• W1998698850 countsByYear W19986988502020 @default.
• W1998698850 countsByYear W19986988502021 @default.
• W1998698850 countsByYear W19986988502022 @default.
• W1998698850 crossrefType "journal-article" @default.
• W1998698850 hasAuthorship W1998698850A5050217177 @default.
• W1998698850 hasAuthorship W1998698850A5061369313 @default.
• W1998698850 hasBestOaLocation W19986988501 @default.
• W1998698850 hasConcept C101762097 @default.
• W1998698850 hasConcept C104317684 @default.
• W1998698850 hasConcept C138885662 @default.
• W1998698850 hasConcept C144825837 @default.
• W1998698850 hasConcept C150194340 @default.
• W1998698850 hasConcept C153911025 @default.
• W1998698850 hasConcept C172768829 @default.
• W1998698850 hasConcept C179926584 @default.
• W1998698850 hasConcept C196117886 @default.
• W1998698850 hasConcept C2776449523 @default.
• W1998698850 hasConcept C41895202 @default.
• W1998698850 hasConcept C54355233 @default.
• W1998698850 hasConcept C64350747 @default.
• W1998698850 hasConcept C67705224 @default.
• W1998698850 hasConcept C86803240 @default.
• W1998698850 hasConceptScore W1998698850C101762097 @default.
• W1998698850 hasConceptScore W1998698850C104317684 @default.
• W1998698850 hasConceptScore W1998698850C138885662 @default.
• W1998698850 hasConceptScore W1998698850C144825837 @default.
• W1998698850 hasConceptScore W1998698850C150194340 @default.
• W1998698850 hasConceptScore W1998698850C153911025 @default.
• W1998698850 hasConceptScore W1998698850C172768829 @default.
• W1998698850 hasConceptScore W1998698850C179926584 @default.
• W1998698850 hasConceptScore W1998698850C196117886 @default.
• W1998698850 hasConceptScore W1998698850C2776449523 @default.
• W1998698850 hasConceptScore W1998698850C41895202 @default.
• W1998698850 hasConceptScore W1998698850C54355233 @default.
• W1998698850 hasConceptScore W1998698850C64350747 @default.
• W1998698850 hasConceptScore W1998698850C67705224 @default.
• W1998698850 hasConceptScore W1998698850C86803240 @default.
• W1998698850 hasIssue "1" @default.
• W1998698850 hasLocation W19986988501 @default.
• W1998698850 hasLocation W19986988502 @default.
• W1998698850 hasLocation W19986988503 @default.
• W1998698850 hasLocation W19986988504 @default.
• W1998698850 hasOpenAccess W1998698850 @default.

• next