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• W1998700890 abstract "Cod liver oil (CLO) is a rich source of omega-3 fatty acids (FA), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The existing data suggest that EPA and DHA are the active agents of fish oil. In this study, we tested a hypothesis that the active constituents of CLO alleviate the negative impact of prolonged restraint stress on cognitive functions of male Wistar rats. Specifically, we attempted to characterize the preventive action of long-lasting treatment with CLO [0.375 ml/100 g body weight (equivalent to a dose of 300 mg/kg DHA and 225 mg/kg EPA), p.o. for 21 days] against an impairment caused by chronic restraint stress (2 h daily for 21 days) on recall as tested in a passive avoidance situation and on the spatial reference and working memory tested in a Barnes maze as well as on locomotor activity and anxiety behavior tested respectively in an open field and elevated plus-maze. We found that CLO administration statistically significantly (p < 0.01, both) prevented the deleterious effects of chronic restraint stress on recall and the spatial memory." @default.
• W1998700890 created "2016-06-24" @default.
• W1998700890 creator A5045079384 @default.
• W1998700890 creator A5085867764 @default.
• W1998700890 date "2011-03-26" @default.
• W1998700890 modified "2023-09-25" @default.
• W1998700890 title "Long‐Term Administration of Cod Liver Oil Ameliorates Cognitive Impairment Induced by Chronic Stress in Rats" @default.
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• W1998700890 doi "https://doi.org/10.1007/s11745-011-3551-3" @default.
• W1998700890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21442272" @default.
• W1998700890 hasPublicationYear "2011" @default.
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