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- W1998711259 abstract "Abstract Divalent ions, which block Ca2+ currents, combined with partial block of outward currents give rise to slow plateau-like oscillations (10–50 s period) with long duration plateaus and long inter-plateau intervals in leech heart interneurons (Opdyke, Calabrese, J. Comp. Physiol. 175 (1994) 781–789.) We present a simplified mathematical model that replicates the main characteristics of these observations and suggests an underlying biophysical mechanism. A model containing transient Na+ current (INa), leakage and outward currents can generate oscillations with long plateau duration. The plateaus arise from a window mode of INa and do not require noninactivating Na+ current (IP). The long inter-plateau intervals are produced reliably after including IP." @default.
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- W1998711259 date "2001-06-01" @default.
- W1998711259 modified "2023-09-26" @default.
- W1998711259 title "A model of slow plateau-like oscillations based upon the fast Na+ current in a window mode" @default.
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- W1998711259 doi "https://doi.org/10.1016/s0925-2312(01)00414-3" @default.
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