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• W1998717812 endingPage "14" @default.
• W1998717812 startingPage "1" @default.
• W1998717812 abstract "Hepatitis C virus (HCV) is a modern-day pandemic; 2–3% of the world's population are thought to be infected with the virus and are subsequently at risk of developing end-stage liver diseases. The traditional standard of care (SOC) for HCV-infected patients has been limited to a regimen of pegylated-interferon alpha (pegIFN) and ribavirin; displaying low cure rates in a majority of patients and severe side effects. However, in 2011 the first direct-acting antivirals (DAA) were licensed to treat HCV-infected patients in combination with SOC, which served to elevate treatment response rates. The HCV drug development pipeline is currently populated with many additional and improved DAAs; primarily molecules that target the virus-encoded protease or polymerase enzymes. These molecules are being evaluated both in combination with the traditional SOC and together with other DAAs as all-oral pegIFN-free regimens with the ultimate goal of developing multiple DAA-containing HCV therapies that do not rely on an pegIFN backbone. A recent addition to the arsenal of HCV inhibitors in development is represented by an entirely new DAA class; molecules that target the HCV-encoded non-enzymatic NS5A protein. NS5A is essential for HCV propagation and, although its actual functions are largely unknown, it is likely a key regulator of viral genome replication and virion assembly. The protein is exquisitely sensitive to small molecule-mediated inhibition; NS5A-targeting molecules are probably the most potent antiviral molecules ever discovered and exhibit a number of other attractive drug-like properties, including activity against many HCV genotypes/subtypes and once-daily dosing potential. Although their mechanism of action is unclear, NS5A-targeting molecules are already proving their utility in clinical evaluation; particularly as components of pegIFN-sparring DAA combination regimens. This review will aim to amalgamate our current understanding and knowledge of NS5A-targeting molecules; their discovery, properties, applications, and insight into their future impact as components of all-oral pegIFN-free DAA combination therapies to combat HCV infection." @default.
• W1998717812 created "2016-06-24" @default.
• W1998717812 creator A5017845170 @default.
• W1998717812 creator A5020366274 @default.
• W1998717812 date "2012-12-01" @default.
• W1998717812 modified "2023-09-26" @default.
• W1998717812 title "Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein" @default.
• W1998717812 cites W1831899697 @default.
• W1998717812 cites W1895993106 @default.
• W1998717812 cites W1956249391 @default.
• W1998717812 cites W1972440189 @default.
• W1998717812 cites W1974464383 @default.
• W1998717812 cites W1975166422 @default.
• W1998717812 cites W1978461683 @default.
• W1998717812 cites W1979574442 @default.
• W1998717812 cites W1981385281 @default.
• W1998717812 cites W1982315879 @default.
• W1998717812 cites W1982628122 @default.
• W1998717812 cites W1983906683 @default.
• W1998717812 cites W1984150038 @default.
• W1998717812 cites W1985055250 @default.
• W1998717812 cites W1986445856 @default.
• W1998717812 cites W1988673850 @default.
• W1998717812 cites W1989409598 @default.
• W1998717812 cites W1990552018 @default.
• W1998717812 cites W1992212684 @default.
• W1998717812 cites W1992987492 @default.
• W1998717812 cites W1993681618 @default.
• W1998717812 cites W1993790328 @default.
• W1998717812 cites W1995591620 @default.
• W1998717812 cites W1997249384 @default.
• W1998717812 cites W1998093640 @default.
• W1998717812 cites W1999256547 @default.
• W1998717812 cites W2003104968 @default.
• W1998717812 cites W2003515023 @default.
• W1998717812 cites W2007987493 @default.
• W1998717812 cites W2009054488 @default.
• W1998717812 cites W2010120205 @default.
• W1998717812 cites W2012808888 @default.
• W1998717812 cites W2014285805 @default.
• W1998717812 cites W2019915078 @default.
• W1998717812 cites W2022474281 @default.
• W1998717812 cites W2022869504 @default.
• W1998717812 cites W2023890954 @default.
• W1998717812 cites W2024036277 @default.
• W1998717812 cites W2027792646 @default.
• W1998717812 cites W2030439961 @default.
• W1998717812 cites W2032451726 @default.
• W1998717812 cites W2033125798 @default.
• W1998717812 cites W2042546035 @default.
• W1998717812 cites W2044208938 @default.
• W1998717812 cites W2045904546 @default.
• W1998717812 cites W2048319398 @default.
• W1998717812 cites W2050997685 @default.
• W1998717812 cites W2054768505 @default.
• W1998717812 cites W2056622178 @default.
• W1998717812 cites W2057967679 @default.
• W1998717812 cites W2059530064 @default.
• W1998717812 cites W2060483294 @default.
• W1998717812 cites W2060735361 @default.
• W1998717812 cites W2063638629 @default.
• W1998717812 cites W2065381342 @default.
• W1998717812 cites W2067982949 @default.
• W1998717812 cites W2068128206 @default.
• W1998717812 cites W2069597046 @default.
• W1998717812 cites W2070142902 @default.
• W1998717812 cites W2070587341 @default.
• W1998717812 cites W2071481565 @default.
• W1998717812 cites W2075557556 @default.
• W1998717812 cites W2076986683 @default.
• W1998717812 cites W2077103006 @default.
• W1998717812 cites W2077675989 @default.
• W1998717812 cites W2077914145 @default.
• W1998717812 cites W2078450406 @default.
• W1998717812 cites W2078887917 @default.
• W1998717812 cites W2085026126 @default.
• W1998717812 cites W2085304196 @default.
• W1998717812 cites W2087587204 @default.
• W1998717812 cites W2089962959 @default.
• W1998717812 cites W2090825777 @default.
• W1998717812 cites W2091073445 @default.
• W1998717812 cites W2091247559 @default.
• W1998717812 cites W2092333889 @default.
• W1998717812 cites W2093137226 @default.
• W1998717812 cites W2096604412 @default.
• W1998717812 cites W2096803801 @default.
• W1998717812 cites W2096820648 @default.
• W1998717812 cites W2096908534 @default.
• W1998717812 cites W2098432187 @default.
• W1998717812 cites W2098451349 @default.
• W1998717812 cites W2100096299 @default.
• W1998717812 cites W2103319039 @default.
• W1998717812 cites W2105891409 @default.
• W1998717812 cites W2106239124 @default.
• W1998717812 cites W2110053131 @default.
• W1998717812 cites W2110309669 @default.
• W1998717812 cites W2110671968 @default.
• W1998717812 cites W2110711266 @default.

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