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• W1998718877 abstract "The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations. This prompted us to test the BH3-mimetic compound ABT-737 for its ability to eradicate putative leukemic stem cells. ABT-737 demonstrated potent cytotoxic effects in all patient samples tested. The efficacy of ABT-737 against AML blasts and the primitive CD34+/CD38− population was equal and independent of sensitivity to cytarabine/daunorubicin. These results, together with previously reported synergistic effects of ABT-737 with chemotherapeutics make BH3-mimetics promising candidates for future AML treatment regimens." @default.
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• W1998718877 date "2014-01-01" @default.
• W1998718877 modified "2023-10-16" @default.
• W1998718877 title "The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells" @default.
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• W1998718877 doi "https://doi.org/10.1016/j.lrr.2014.06.001" @default.
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