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• W1998722598 abstract "<i>Background:</i> Our objectives were to assess the pharmacokinetic interaction and body fluid penetration of ciprofloxacin and levofloxacin. <i>Methods:</i> This study was a single-dose open randomized three-way crossover in 15 healthy volunteers receiving 500 mg oral levofloxacin, 500 mg oral ciprofloxacin, or 250 mg levofloxacin and 250 mg ciprofloxacin co-administered. Serum, urine, and body fluid concentrations were determined by high-performance liquid chromatography and analyzed via population pharmacokinetic modeling. <i>Results:</i> Modeling indicated that ciprofloxacin inhibited the renal reabsorption of levofloxacin. Ciprofloxacin increased the net renal clearance of levofloxacin by 13%, as its estimated affinity for a putative tubular reabsorption transporter was 12-fold higher (Km: 568 µ<i>M</i>) compared to levofloxacin (Km: 6,830 µ<i>M</i>). Levofloxacin increased the bioavailability of ciprofloxacin by 12% and achieved significantly (p < 0.05) higher concentrations at 3 h in ejaculate, prostatic, seminal, and vaginal fluid compared to ciprofloxacin. <i>Conclusion:</i> Modeling suggested that ciprofloxacin inhibited the tubular reabsorption of levofloxacin due to a 12-fold higher affinity for a putative tubular reabsorption transporter compared to levofloxacin. This pharmacokinetic interaction was not clinically relevant." @default.
• W1998722598 created "2016-06-24" @default.
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• W1998722598 date "2011-01-01" @default.
• W1998722598 modified "2023-10-17" @default.
• W1998722598 title "Population Pharmacokinetics and Penetration into Prostatic, Seminal, and Vaginal Fluid for Ciprofloxacin, Levofloxacin, and Their Combination" @default.
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• W1998722598 doi "https://doi.org/10.1159/000329520" @default.
• W1998722598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22024700" @default.
• W1998722598 hasPublicationYear "2011" @default.
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