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- W1998725166 abstract "The psychostimulants methylphenidate (Ritalin, Concerta), amphetamine (Adderall), and modafinil (Provigil) are widely used in the treatment of medical conditions such as attention-deficit hyperactivity disorder and narcolepsy and, increasingly, as cognitive enhancers by healthy people. The long-term neuronal effects of these drugs, however, are poorly understood. A substantial amount of research over the past two decades has investigated the effects of psychostimulants such as cocaine and amphetamines on gene regulation in the brain because these molecular changes are considered critical for psychostimulant addiction. This work has determined in some detail the neurochemical and cellular mechanisms that mediate psychostimulant-induced gene regulation and has also identified the neuronal systems altered by these drugs. Among the most affected brain systems are corticostriatal circuits, which are part of cortico-basal ganglia-cortical loops that mediate motivated behavior. The neurotransmitters critical for such gene regulation are dopamine in interaction with glutamate, while other neurotransmitters (e.g., serotonin) play modulatory roles. This review presents (1) an overview of the main findings on cocaine- and amphetamine-induced gene regulation in corticostriatal circuits in an effort to provide a cellular framework for (2) an assessment of the molecular changes produced by methylphenidate, medical amphetamine (Adderall), and modafinil. The findings lead to the conclusion that protracted exposure to these cognitive enhancers can induce gene regulation effects in corticostriatal circuits that are qualitatively similar to those of cocaine and other amphetamines. These neuronal changes may contribute to the addiction liability of the psychostimulant cognitive enhancers." @default.
- W1998725166 created "2016-06-24" @default.
- W1998725166 creator A5025030166 @default.
- W1998725166 creator A5060032880 @default.
- W1998725166 date "2013-01-01" @default.
- W1998725166 modified "2023-10-16" @default.
- W1998725166 title "Addiction-related gene regulation: Risks of exposure to cognitive enhancers vs. other psychostimulants" @default.
- W1998725166 cites W131682327 @default.
- W1998725166 cites W1479941912 @default.
- W1998725166 cites W1497175107 @default.
- W1998725166 cites W1506920637 @default.
- W1998725166 cites W1531239488 @default.
- W1998725166 cites W1536614704 @default.
- W1998725166 cites W1544761270 @default.
- W1998725166 cites W1545165210 @default.
- W1998725166 cites W1550776377 @default.
- W1998725166 cites W1563094024 @default.
- W1998725166 cites W1582315344 @default.
- W1998725166 cites W1590331644 @default.
- W1998725166 cites W1593383161 @default.
- W1998725166 cites W1594303110 @default.
- W1998725166 cites W1608908265 @default.
- W1998725166 cites W1617955079 @default.
- W1998725166 cites W1798056883 @default.
- W1998725166 cites W1828572233 @default.
- W1998725166 cites W1913760354 @default.
- W1998725166 cites W1945000294 @default.
- W1998725166 cites W1953561962 @default.
- W1998725166 cites W1963788736 @default.
- W1998725166 cites W1964374986 @default.
- W1998725166 cites W1964386076 @default.
- W1998725166 cites W1964751335 @default.
- W1998725166 cites W1965272207 @default.
- W1998725166 cites W1965719218 @default.
- W1998725166 cites W1966708273 @default.
- W1998725166 cites W1966785145 @default.
- W1998725166 cites W1966928184 @default.
- W1998725166 cites W1966980993 @default.
- W1998725166 cites W1967694617 @default.
- W1998725166 cites W1967709130 @default.
- W1998725166 cites W1968307109 @default.
- W1998725166 cites W1968606629 @default.
- W1998725166 cites W1968629676 @default.
- W1998725166 cites W1970031540 @default.
- W1998725166 cites W1970596496 @default.
- W1998725166 cites W1971465282 @default.
- W1998725166 cites W1971797700 @default.
- W1998725166 cites W1973330712 @default.
- W1998725166 cites W1973895343 @default.
- W1998725166 cites W1973975463 @default.
- W1998725166 cites W1975744829 @default.
- W1998725166 cites W1976032083 @default.
- W1998725166 cites W1976828528 @default.
- W1998725166 cites W1977418293 @default.
- W1998725166 cites W1977478218 @default.
- W1998725166 cites W1977533543 @default.
- W1998725166 cites W1977634040 @default.
- W1998725166 cites W1978334957 @default.
- W1998725166 cites W1979266375 @default.
- W1998725166 cites W1979384413 @default.
- W1998725166 cites W1979447206 @default.
- W1998725166 cites W1980167997 @default.
- W1998725166 cites W1980494785 @default.
- W1998725166 cites W1980727604 @default.
- W1998725166 cites W1980778878 @default.
- W1998725166 cites W1980789028 @default.
- W1998725166 cites W1982243354 @default.
- W1998725166 cites W1982653585 @default.
- W1998725166 cites W1982827121 @default.
- W1998725166 cites W1986105672 @default.
- W1998725166 cites W1987164572 @default.
- W1998725166 cites W1987459299 @default.
- W1998725166 cites W1987911844 @default.
- W1998725166 cites W1991603311 @default.
- W1998725166 cites W1992430235 @default.
- W1998725166 cites W1993624518 @default.
- W1998725166 cites W1994478298 @default.
- W1998725166 cites W1995992264 @default.
- W1998725166 cites W1996651938 @default.
- W1998725166 cites W1997765732 @default.
- W1998725166 cites W1998147949 @default.
- W1998725166 cites W1998335883 @default.
- W1998725166 cites W2001805825 @default.
- W1998725166 cites W2001997032 @default.
- W1998725166 cites W2003010986 @default.
- W1998725166 cites W2004757843 @default.
- W1998725166 cites W2004772633 @default.
- W1998725166 cites W2005548160 @default.
- W1998725166 cites W2005657014 @default.
- W1998725166 cites W2006977548 @default.
- W1998725166 cites W2007647538 @default.
- W1998725166 cites W2007754730 @default.
- W1998725166 cites W2008388130 @default.
- W1998725166 cites W2008526948 @default.
- W1998725166 cites W2008616448 @default.
- W1998725166 cites W2008905841 @default.
- W1998725166 cites W2009436984 @default.
- W1998725166 cites W2009449932 @default.