FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998746711> ?p ?o ?g. }

• W1998746711 endingPage "e19934" @default.
• W1998746711 startingPage "e19934" @default.
• W1998746711 abstract "Introduction The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets. Subjects and Methods This research is based on the NUGENOB study, a trial conducted to assess weight loss during a 10-week dietary intervention involving two different hypo-energetic (high-fat and low-fat) diets. A total of 760 obese patients were genotyped for 10 single nucleotide polymorphisms covering the single exon of MC3R gene and its flanking regions, including the missense variants Thr6Lys and Val81Ile. Linear mixed models and haplotype-based analysis were carried out to assess the potential association between genetic polymorphisms and differential weight loss, fat mass loss, waist change and resting energy expenditure changes. Results No differences in drop-out rate were found by MC3R genotypes. The rs6014646 polymorphism was significantly associated with weight loss using co-dominant (p = 0.04) and dominant models (p = 0.03). These p-values were not statistically significant after strict control for multiple testing. Haplotype-based multivariate analysis using permutations showed that rs3827103–rs1543873 (p = 0.06), rs6014646–rs6024730 (p = 0.05) and rs3746619–rs3827103 (p = 0.10) displayed near-statistical significant results in relation to weight loss. No other significant associations or gene*diet interactions were detected for weight loss, fat mass loss, waist change and resting energy expenditure changes. Conclusion The study provided overall sufficient evidence to support that there is no major effect of genetic variants of MC3R and differential weight loss after a 10-week dietary intervention with hypo-energetic diets in obese Europeans." @default.
• W1998746711 created "2016-06-24" @default.
• W1998746711 creator A5002724781 @default.
• W1998746711 creator A5003940500 @default.
• W1998746711 creator A5011514095 @default.
• W1998746711 creator A5017405033 @default.
• W1998746711 creator A5024203094 @default.
• W1998746711 creator A5048067129 @default.
• W1998746711 creator A5058630661 @default.
• W1998746711 creator A5059730125 @default.
• W1998746711 creator A5063552729 @default.
• W1998746711 creator A5063705490 @default.
• W1998746711 creator A5066298648 @default.
• W1998746711 creator A5066665434 @default.
• W1998746711 creator A5081321830 @default.
• W1998746711 creator A5081645468 @default.
• W1998746711 date "2011-06-14" @default.
• W1998746711 modified "2023-09-23" @default.
• W1998746711 title "Allelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets" @default.
• W1998746711 cites W1486660758 @default.
• W1998746711 cites W1488596761 @default.
• W1998746711 cites W1963755841 @default.
• W1998746711 cites W1968518710 @default.
• W1998746711 cites W1975810881 @default.
• W1998746711 cites W1981663411 @default.
• W1998746711 cites W1986193545 @default.
• W1998746711 cites W1990119407 @default.
• W1998746711 cites W1991780509 @default.
• W1998746711 cites W1992883962 @default.
• W1998746711 cites W1995050609 @default.
• W1998746711 cites W2017540257 @default.
• W1998746711 cites W2022435609 @default.
• W1998746711 cites W2029220352 @default.
• W1998746711 cites W2029342409 @default.
• W1998746711 cites W2038510532 @default.
• W1998746711 cites W2040147853 @default.
• W1998746711 cites W2041811148 @default.
• W1998746711 cites W2053297692 @default.
• W1998746711 cites W2065229011 @default.
• W1998746711 cites W2083539491 @default.
• W1998746711 cites W2084819898 @default.
• W1998746711 cites W2098181391 @default.
• W1998746711 cites W2098830650 @default.
• W1998746711 cites W2102807338 @default.
• W1998746711 cites W2104815712 @default.
• W1998746711 cites W2104873388 @default.
• W1998746711 cites W2111150409 @default.
• W1998746711 cites W2116365106 @default.
• W1998746711 cites W2116703717 @default.
• W1998746711 cites W2117501415 @default.
• W1998746711 cites W2131696669 @default.
• W1998746711 cites W2151349537 @default.
• W1998746711 cites W2153964710 @default.
• W1998746711 cites W2163144326 @default.
• W1998746711 cites W2169149475 @default.
• W1998746711 cites W2186552966 @default.
• W1998746711 doi "https://doi.org/10.1371/journal.pone.0019934" @default.
• W1998746711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3114803" @default.
• W1998746711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21695122" @default.
• W1998746711 hasPublicationYear "2011" @default.
• W1998746711 type Work @default.
• W1998746711 sameAs 1998746711 @default.
• W1998746711 citedByCount "27" @default.
• W1998746711 countsByYear W19987467112012 @default.
• W1998746711 countsByYear W19987467112013 @default.
• W1998746711 countsByYear W19987467112014 @default.
• W1998746711 countsByYear W19987467112015 @default.
• W1998746711 countsByYear W19987467112016 @default.
• W1998746711 countsByYear W19987467112017 @default.
• W1998746711 countsByYear W19987467112018 @default.
• W1998746711 countsByYear W19987467112019 @default.
• W1998746711 countsByYear W19987467112020 @default.
• W1998746711 countsByYear W19987467112021 @default.
• W1998746711 countsByYear W19987467112023 @default.
• W1998746711 crossrefType "journal-article" @default.
• W1998746711 hasAuthorship W1998746711A5002724781 @default.
• W1998746711 hasAuthorship W1998746711A5003940500 @default.
• W1998746711 hasAuthorship W1998746711A5011514095 @default.
• W1998746711 hasAuthorship W1998746711A5017405033 @default.
• W1998746711 hasAuthorship W1998746711A5024203094 @default.
• W1998746711 hasAuthorship W1998746711A5048067129 @default.
• W1998746711 hasAuthorship W1998746711A5058630661 @default.
• W1998746711 hasAuthorship W1998746711A5059730125 @default.
• W1998746711 hasAuthorship W1998746711A5063552729 @default.
• W1998746711 hasAuthorship W1998746711A5063705490 @default.
• W1998746711 hasAuthorship W1998746711A5066298648 @default.
• W1998746711 hasAuthorship W1998746711A5066665434 @default.
• W1998746711 hasAuthorship W1998746711A5081321830 @default.
• W1998746711 hasAuthorship W1998746711A5081645468 @default.
• W1998746711 hasBestOaLocation W19987467111 @default.
• W1998746711 hasConcept C104317684 @default.
• W1998746711 hasConcept C126322002 @default.
• W1998746711 hasConcept C134018914 @default.
• W1998746711 hasConcept C135763542 @default.
• W1998746711 hasConcept C153209595 @default.
• W1998746711 hasConcept C170493617 @default.
• W1998746711 hasConcept C180754005 @default.
• W1998746711 hasConcept C197754878 @default.

• next