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• W1998751899 abstract "The influence of the methylation of the 2′-hydroxyl groups in poly A on its structure in weakly acidic and neutral solutions and on its capability to form ordered complexes with poly U has been investigated by ultraviolet and circular dichroism spectroscopy. A major effect of the methylation of the backbone is to increase the thermal stability of the double-stranded, acid structure of poly A, while no significant effect on the single-stranded conformation was observed. The dissymmetric structures, as reflected in the circular dichroic spectra, were virtually identical for poly A and poly Am§ for the tightly packed, double-stranded, acid structures (pH 4.6, 0.15 m-KCl) on one hand and for the single-stranded conformations (pH 7, 0.15 m-KCl, 25 °C) on the other. Circular dichroic spectra with characteristics intermediate between those of the tightly packed, double-stranded and the single-stranded structures of poly A and poly Am are obtained in the pH range from 5 to 7 at moderate to high ionic strength (for poly Am e.g. at pH 5.7, 0.15 m-NaCl, 4 to 44 °C). From the circular dichroic spectra and absorbance melting profiles it is tentatively concluded that poly A and poly Am form less tightly packed, less ordered double-stranded structures under these conditions. Methylation of the 2′-hydroxyl groups in poly A has virtually no effect on the thermal stability of its double-stranded complex with poly U, but considerably weakens the attachment of the third strand of poly U in poly(Am + 2U). It is concluded that the presence of an unsubstituted 2′-hydroxyl group in poly A is not essential for the stabilization of the double-stranded conformations of poly A in acidic solutions, for the partially-ordered single-stranded conformation of poly A at neutrality or for the double-stranded complex of poly A with poly U." @default.
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• W1998751899 date "1969-12-01" @default.
• W1998751899 modified "2023-09-25" @default.
• W1998751899 title "Effect of the methylation of the 2′-hydroxyl groups in polyadenylic acid on its structure in weakly acidic and neutral solutions and on its capability to form ordered complexes with polyuridylic acid" @default.
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• W1998751899 doi "https://doi.org/10.1016/0022-2836(69)90418-5" @default.
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