Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998763094> ?p ?o ?g. }
- W1998763094 endingPage "862" @default.
- W1998763094 startingPage "855" @default.
- W1998763094 abstract "The interaction of oxidized insulin B chain (B) with cis-[Pd(en)Cl2] (en=ethylenediamine), cis-[Pd-(dtco-3-OH)Cl2] (dtco-3-OH= dithiacyclooctan-3-ol) and CuCl2 was studied by electrospray mass spectrometry. It is discovered that the binding of Pd(II) complexes and the sites of cleavage are highly dependent on the secondary structure and local environment of B. The hydrolytic cleavage of denatured B by Pd(II) complexes was monitored by HPLC. The reaction is regioselective and follows first order kinetics with half-life of 4.8 days at 40oC. Two amide bonds, i. e. at Leu6-Cys7 and at Gly8-Ser9, which are dose to the two potential Pd(II) binding sites His5 and His10, are selectively cleaved. In the case of Cu(II) ion as promoter, only one cleavage site was observed which is located at Gly8-Ser9 bond. These results provide improved understanding on the design of artificial metallopeptidase." @default.
- W1998763094 created "2016-06-24" @default.
- W1998763094 creator A5000366485 @default.
- W1998763094 creator A5049331166 @default.
- W1998763094 creator A5062034580 @default.
- W1998763094 creator A5062874646 @default.
- W1998763094 creator A5071773009 @default.
- W1998763094 date "2010-08-27" @default.
- W1998763094 modified "2023-09-29" @default.
- W1998763094 title "Metal compound-mediated hydrolytic cleavage of oxidized insulin B chain: Regioselectivity and influence of peptide secondary structure" @default.
- W1998763094 cites W1875728332 @default.
- W1998763094 cites W1968381941 @default.
- W1998763094 cites W1981939025 @default.
- W1998763094 cites W1990874228 @default.
- W1998763094 cites W1993226322 @default.
- W1998763094 cites W2000861702 @default.
- W1998763094 cites W2002203770 @default.
- W1998763094 cites W2014062179 @default.
- W1998763094 cites W2015865593 @default.
- W1998763094 cites W2019813190 @default.
- W1998763094 cites W2021623373 @default.
- W1998763094 cites W2021979860 @default.
- W1998763094 cites W2030795694 @default.
- W1998763094 cites W2035158526 @default.
- W1998763094 cites W2037475472 @default.
- W1998763094 cites W2043281814 @default.
- W1998763094 cites W2055415778 @default.
- W1998763094 cites W2056329905 @default.
- W1998763094 cites W2073862147 @default.
- W1998763094 cites W2075659245 @default.
- W1998763094 cites W2076261878 @default.
- W1998763094 cites W207768927 @default.
- W1998763094 cites W2080200948 @default.
- W1998763094 cites W2088843615 @default.
- W1998763094 cites W2091593116 @default.
- W1998763094 cites W2094777596 @default.
- W1998763094 cites W2111915983 @default.
- W1998763094 cites W2414829511 @default.
- W1998763094 doi "https://doi.org/10.1002/cjoc.20000180611" @default.
- W1998763094 hasPublicationYear "2010" @default.
- W1998763094 type Work @default.
- W1998763094 sameAs 1998763094 @default.
- W1998763094 citedByCount "11" @default.
- W1998763094 countsByYear W19987630942015 @default.
- W1998763094 countsByYear W19987630942016 @default.
- W1998763094 crossrefType "journal-article" @default.
- W1998763094 hasAuthorship W1998763094A5000366485 @default.
- W1998763094 hasAuthorship W1998763094A5049331166 @default.
- W1998763094 hasAuthorship W1998763094A5062034580 @default.
- W1998763094 hasAuthorship W1998763094A5062874646 @default.
- W1998763094 hasAuthorship W1998763094A5071773009 @default.
- W1998763094 hasConcept C127413603 @default.
- W1998763094 hasConcept C161790260 @default.
- W1998763094 hasConcept C175156509 @default.
- W1998763094 hasConcept C178790620 @default.
- W1998763094 hasConcept C185592680 @default.
- W1998763094 hasConcept C187320778 @default.
- W1998763094 hasConcept C2778439535 @default.
- W1998763094 hasConcept C2779281246 @default.
- W1998763094 hasConcept C2780728571 @default.
- W1998763094 hasConcept C3044715 @default.
- W1998763094 hasConcept C31684184 @default.
- W1998763094 hasConcept C43369102 @default.
- W1998763094 hasConcept C55493867 @default.
- W1998763094 hasConcept C59759590 @default.
- W1998763094 hasConcept C71240020 @default.
- W1998763094 hasConcept C94412978 @default.
- W1998763094 hasConceptScore W1998763094C127413603 @default.
- W1998763094 hasConceptScore W1998763094C161790260 @default.
- W1998763094 hasConceptScore W1998763094C175156509 @default.
- W1998763094 hasConceptScore W1998763094C178790620 @default.
- W1998763094 hasConceptScore W1998763094C185592680 @default.
- W1998763094 hasConceptScore W1998763094C187320778 @default.
- W1998763094 hasConceptScore W1998763094C2778439535 @default.
- W1998763094 hasConceptScore W1998763094C2779281246 @default.
- W1998763094 hasConceptScore W1998763094C2780728571 @default.
- W1998763094 hasConceptScore W1998763094C3044715 @default.
- W1998763094 hasConceptScore W1998763094C31684184 @default.
- W1998763094 hasConceptScore W1998763094C43369102 @default.
- W1998763094 hasConceptScore W1998763094C55493867 @default.
- W1998763094 hasConceptScore W1998763094C59759590 @default.
- W1998763094 hasConceptScore W1998763094C71240020 @default.
- W1998763094 hasConceptScore W1998763094C94412978 @default.
- W1998763094 hasIssue "6" @default.
- W1998763094 hasLocation W19987630941 @default.
- W1998763094 hasOpenAccess W1998763094 @default.
- W1998763094 hasPrimaryLocation W19987630941 @default.
- W1998763094 hasRelatedWork W1964001288 @default.
- W1998763094 hasRelatedWork W2003068062 @default.
- W1998763094 hasRelatedWork W2013215599 @default.
- W1998763094 hasRelatedWork W2015914885 @default.
- W1998763094 hasRelatedWork W2039067763 @default.
- W1998763094 hasRelatedWork W2046482444 @default.
- W1998763094 hasRelatedWork W2067057180 @default.
- W1998763094 hasRelatedWork W2256916702 @default.
- W1998763094 hasRelatedWork W2914310478 @default.
- W1998763094 hasRelatedWork W4307019547 @default.
- W1998763094 hasVolume "18" @default.