Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998771362> ?p ?o ?g. }
- W1998771362 endingPage "401" @default.
- W1998771362 startingPage "390" @default.
- W1998771362 abstract "Dysfunctional mTORC1 signaling is associated with a number of human pathologies owing to its central role in controlling cell growth, proliferation, and metabolism. Regulation of mTORC1 is achieved by the integration of multiple inputs, including those of mitogens, nutrients, and energy. It is thought that agents that increase the cellular AMP/ATP ratio, such as the antidiabetic biguanides metformin and phenformin, inhibit mTORC1 through AMPK activation of TSC1/2-dependent or -independent mechanisms. Unexpectedly, we found that biguanides inhibit mTORC1 signaling, not only in the absence of TSC1/2 but also in the absence of AMPK. Consistent with these observations, in two distinct preclinical models of cancer and diabetes, metformin acts to suppress mTORC1 signaling in an AMPK-independent manner. We found that the ability of biguanides to inhibit mTORC1 activation and signaling is, instead, dependent on the Rag GTPases." @default.
- W1998771362 created "2016-06-24" @default.
- W1998771362 creator A5007768979 @default.
- W1998771362 creator A5013722838 @default.
- W1998771362 creator A5016181950 @default.
- W1998771362 creator A5027050582 @default.
- W1998771362 creator A5035433279 @default.
- W1998771362 creator A5036847916 @default.
- W1998771362 creator A5045765280 @default.
- W1998771362 creator A5056027263 @default.
- W1998771362 creator A5061636268 @default.
- W1998771362 creator A5064406116 @default.
- W1998771362 creator A5066736367 @default.
- W1998771362 creator A5084022982 @default.
- W1998771362 creator A5085534684 @default.
- W1998771362 date "2010-05-01" @default.
- W1998771362 modified "2023-10-10" @default.
- W1998771362 title "Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner" @default.
- W1998771362 cites W1526728261 @default.
- W1998771362 cites W1536070820 @default.
- W1998771362 cites W1830229895 @default.
- W1998771362 cites W1968513003 @default.
- W1998771362 cites W1970707895 @default.
- W1998771362 cites W1971556742 @default.
- W1998771362 cites W1980359753 @default.
- W1998771362 cites W1984621921 @default.
- W1998771362 cites W1984674883 @default.
- W1998771362 cites W1996021619 @default.
- W1998771362 cites W1997732325 @default.
- W1998771362 cites W2001568034 @default.
- W1998771362 cites W2004582874 @default.
- W1998771362 cites W2006559495 @default.
- W1998771362 cites W2008294451 @default.
- W1998771362 cites W2009810346 @default.
- W1998771362 cites W2010238890 @default.
- W1998771362 cites W2011872098 @default.
- W1998771362 cites W2014129554 @default.
- W1998771362 cites W2022461483 @default.
- W1998771362 cites W2023455728 @default.
- W1998771362 cites W2025176940 @default.
- W1998771362 cites W2031918765 @default.
- W1998771362 cites W2041502315 @default.
- W1998771362 cites W2044874695 @default.
- W1998771362 cites W2046304613 @default.
- W1998771362 cites W2054943275 @default.
- W1998771362 cites W2054998824 @default.
- W1998771362 cites W2060157525 @default.
- W1998771362 cites W2062997257 @default.
- W1998771362 cites W2064656431 @default.
- W1998771362 cites W2065902143 @default.
- W1998771362 cites W2066659565 @default.
- W1998771362 cites W2078281362 @default.
- W1998771362 cites W2081920342 @default.
- W1998771362 cites W2082853003 @default.
- W1998771362 cites W2085331940 @default.
- W1998771362 cites W2089632625 @default.
- W1998771362 cites W2090611040 @default.
- W1998771362 cites W2102799140 @default.
- W1998771362 cites W2107674876 @default.
- W1998771362 cites W2108360575 @default.
- W1998771362 cites W2119711962 @default.
- W1998771362 cites W2122251892 @default.
- W1998771362 cites W2127632261 @default.
- W1998771362 cites W2130396048 @default.
- W1998771362 cites W2134138119 @default.
- W1998771362 cites W2136676465 @default.
- W1998771362 cites W2136829490 @default.
- W1998771362 cites W2137960344 @default.
- W1998771362 cites W2138226825 @default.
- W1998771362 cites W2138871725 @default.
- W1998771362 cites W2148197020 @default.
- W1998771362 cites W2148652623 @default.
- W1998771362 cites W2150551377 @default.
- W1998771362 cites W2156943914 @default.
- W1998771362 cites W2166307667 @default.
- W1998771362 cites W4238567307 @default.
- W1998771362 cites W4245367233 @default.
- W1998771362 doi "https://doi.org/10.1016/j.cmet.2010.03.014" @default.
- W1998771362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081779" @default.
- W1998771362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20444419" @default.
- W1998771362 hasPublicationYear "2010" @default.
- W1998771362 type Work @default.
- W1998771362 sameAs 1998771362 @default.
- W1998771362 citedByCount "731" @default.
- W1998771362 countsByYear W19987713622012 @default.
- W1998771362 countsByYear W19987713622013 @default.
- W1998771362 countsByYear W19987713622014 @default.
- W1998771362 countsByYear W19987713622015 @default.
- W1998771362 countsByYear W19987713622016 @default.
- W1998771362 countsByYear W19987713622017 @default.
- W1998771362 countsByYear W19987713622018 @default.
- W1998771362 countsByYear W19987713622019 @default.
- W1998771362 countsByYear W19987713622020 @default.
- W1998771362 countsByYear W19987713622021 @default.
- W1998771362 countsByYear W19987713622022 @default.
- W1998771362 countsByYear W19987713622023 @default.
- W1998771362 crossrefType "journal-article" @default.
- W1998771362 hasAuthorship W1998771362A5007768979 @default.