FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998775306> ?p ?o ?g. }

• W1998775306 endingPage "2748" @default.
• W1998775306 startingPage "2741" @default.
• W1998775306 abstract "Sphingosine 1-phosphate (S1P) through its interaction with a family of G protein-coupled receptors (S1PR) is proving to have a significant impact on the activation of a variety of cell types, most notably those cells mediating the inflammatory response. Previously, we showed that S1P enhanced the excitability of small diameter sensory neurons, and mRNA for S1PR(1-4) was expressed in sensory neurons. These initial findings did not determine which S1PR subtype(s) mediated the increased excitability. Here, we report that exposure to the selective S1PR(1) agonist, SEW2871, produced a significant increase in excitability of some, but not all, sensory neurons. To further examine the role of S1PR(1), neurons were treated with siRNA targeted to S1PR(1). siRNA reduced S1PR(1) protein expression by 75% and blocked the sensitization produced by SEW2871, although some neurons remained responsive to subsequent exposure to S1P. Treatment with scramble siRNA did not alter S1PR(1) expression. Recordings from siRNA- and scramble-treated neurons suggested three distinct populations based on their sensitivities to SEW2871 and S1P. Approximately 50% of the neurons exhibited a significant increase in excitability after exposure to SEW2871 and subsequent S1P produced no additional increase; ∼25% were not affected by SEW2871 but S1P significantly increased excitability; and ∼25% of the neurons were not sensitized by either SEW2871 or S1P. RT-PCR measurements obtained from single neurons showed that 50% of the small diameter neurons expressed the mRNA for S1PR(1). These results indicate that S1PR(1) plays a prominent, although not exclusive, role in mediating the enhancement of excitability produced by S1P." @default.
• W1998775306 created "2016-06-24" @default.
• W1998775306 creator A5040577374 @default.
• W1998775306 creator A5085209847 @default.
• W1998775306 date "2010-11-01" @default.
• W1998775306 modified "2023-10-11" @default.
• W1998775306 title "The Sphingosine 1-Phosphate Receptor, S1PR₁, Plays a Prominent But Not Exclusive Role in Enhancing the Excitability of Sensory Neurons" @default.
• W1998775306 cites W1572219834 @default.
• W1998775306 cites W1598200894 @default.
• W1998775306 cites W1608557519 @default.
• W1998775306 cites W1614634778 @default.
• W1998775306 cites W180582650 @default.
• W1998775306 cites W1949045883 @default.
• W1998775306 cites W1956978115 @default.
• W1998775306 cites W1964953009 @default.
• W1998775306 cites W1966452335 @default.
• W1998775306 cites W1967802627 @default.
• W1998775306 cites W1991558659 @default.
• W1998775306 cites W1991624475 @default.
• W1998775306 cites W1994560539 @default.
• W1998775306 cites W2006985918 @default.
• W1998775306 cites W2009667219 @default.
• W1998775306 cites W2011918841 @default.
• W1998775306 cites W2012591726 @default.
• W1998775306 cites W2019209482 @default.
• W1998775306 cites W2020939052 @default.
• W1998775306 cites W2022770236 @default.
• W1998775306 cites W2036222948 @default.
• W1998775306 cites W2037787296 @default.
• W1998775306 cites W2038203316 @default.
• W1998775306 cites W2040299229 @default.
• W1998775306 cites W2044986630 @default.
• W1998775306 cites W2045320332 @default.
• W1998775306 cites W2052365226 @default.
• W1998775306 cites W2059921365 @default.
• W1998775306 cites W2072696125 @default.
• W1998775306 cites W2077885131 @default.
• W1998775306 cites W2082714603 @default.
• W1998775306 cites W2090452143 @default.
• W1998775306 cites W2097482307 @default.
• W1998775306 cites W2104948944 @default.
• W1998775306 cites W2105192692 @default.
• W1998775306 cites W2105218146 @default.
• W1998775306 cites W2108813293 @default.
• W1998775306 cites W2127032203 @default.
• W1998775306 cites W2132579946 @default.
• W1998775306 cites W2137116513 @default.
• W1998775306 cites W2140441724 @default.
• W1998775306 cites W2149918734 @default.
• W1998775306 cites W2150592919 @default.
• W1998775306 cites W2151340435 @default.
• W1998775306 cites W2154089780 @default.
• W1998775306 cites W2162838509 @default.
• W1998775306 cites W2305369714 @default.
• W1998775306 cites W4230277786 @default.
• W1998775306 doi "https://doi.org/10.1152/jn.00709.2010" @default.
• W1998775306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997035" @default.
• W1998775306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20844107" @default.
• W1998775306 hasPublicationYear "2010" @default.
• W1998775306 type Work @default.
• W1998775306 sameAs 1998775306 @default.
• W1998775306 citedByCount "42" @default.
• W1998775306 countsByYear W19987753062012 @default.
• W1998775306 countsByYear W19987753062013 @default.
• W1998775306 countsByYear W19987753062014 @default.
• W1998775306 countsByYear W19987753062015 @default.
• W1998775306 countsByYear W19987753062017 @default.
• W1998775306 countsByYear W19987753062018 @default.
• W1998775306 countsByYear W19987753062019 @default.
• W1998775306 countsByYear W19987753062020 @default.
• W1998775306 countsByYear W19987753062021 @default.
• W1998775306 countsByYear W19987753062022 @default.
• W1998775306 crossrefType "journal-article" @default.
• W1998775306 hasAuthorship W1998775306A5040577374 @default.
• W1998775306 hasAuthorship W1998775306A5085209847 @default.
• W1998775306 hasBestOaLocation W19987753062 @default.
• W1998775306 hasConcept C169760540 @default.
• W1998775306 hasConcept C170493617 @default.
• W1998775306 hasConcept C2776596873 @default.
• W1998775306 hasConcept C2777700496 @default.
• W1998775306 hasConcept C2778703144 @default.
• W1998775306 hasConcept C2778938600 @default.
• W1998775306 hasConcept C55493867 @default.
• W1998775306 hasConcept C86803240 @default.
• W1998775306 hasConcept C94487597 @default.
• W1998775306 hasConcept C95444343 @default.
• W1998775306 hasConceptScore W1998775306C169760540 @default.
• W1998775306 hasConceptScore W1998775306C170493617 @default.
• W1998775306 hasConceptScore W1998775306C2776596873 @default.
• W1998775306 hasConceptScore W1998775306C2777700496 @default.
• W1998775306 hasConceptScore W1998775306C2778703144 @default.
• W1998775306 hasConceptScore W1998775306C2778938600 @default.
• W1998775306 hasConceptScore W1998775306C55493867 @default.
• W1998775306 hasConceptScore W1998775306C86803240 @default.
• W1998775306 hasConceptScore W1998775306C94487597 @default.
• W1998775306 hasConceptScore W1998775306C95444343 @default.
• W1998775306 hasIssue "5" @default.
• W1998775306 hasLocation W19987753061 @default.

• next