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- W1998778866 abstract "Four-stranded G-quadruplex structure is one of the most important non-canonical secondary structures of DNA formed by guanine (G)-rich sequences. G-rich DNA sequences are known to occur in the human genome, especially in the telomere 3' end and in oncogene promoters such as c-MYC and c-KIT. In this context, we designed pyrene-conjugated polyethylenimine (PEI-Py) as a fluorescence reporter for the recognition and detection of G-quadruplex structures of G-rich deoxyoligonucleotides and human telomere and gene promoter sequences, under ambient conditions. PEI-Py exhibited prominent pyrene excimer emission in the presence of G-quadruplex structures of G-rich deoxyoligonucleotides and biologically relevant DNA sequences. PEI-Py further displayed the modulation of DNAzyme activity of various G-quadruplex structures in the presence of hemin and hydrogen peroxide." @default.
- W1998778866 created "2016-06-24" @default.
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- W1998778866 date "2015-06-01" @default.
- W1998778866 modified "2023-10-07" @default.
- W1998778866 title "Fluorescence reporting of G-quadruplex structures and modulating their DNAzyme activity using polyethylenimine–pyrene conjugate" @default.
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- W1998778866 doi "https://doi.org/10.1016/j.bmcl.2015.04.012" @default.
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