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- W1998785024 endingPage "2306" @default.
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- W1998785024 abstract "Seven new phenylspirodrimanes, named stachybotrins D-F (1, 3, 4), stachybocins E and F (5, 6), and stachybosides A and B (7, 8), and four known compounds (2, 9-11), were isolated from the sponge-derived fungus Stachybotrys chartarum MXH-X73. Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1-8 were determined by chemical hydrolysis and modified Mosher's and Marfey's methods. All compounds were tested in an anti-HIV activity assay, and compound 1 showed an inhibitory effect on HIV-1 replication by targeting reverse transcriptase. Further study exhibited that 1 could block NNRTIs-resistant strains (HIV-1RT-K103N, HIV-1RT-L100I,K103N, HIV-1RT-K103N,V108I, HIV-1RT-K103N,G190A, and HIV-1RT-K103N,P225H) as well as wild-type HIV-1 (HIV-1wt) with EC50 values of 7.0, 23.8, 13.3, 14.2, 6.2, and 8.4 μM, respectively." @default.
- W1998785024 created "2016-06-24" @default.
- W1998785024 creator A5000783238 @default.
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- W1998785024 date "2013-12-05" @default.
- W1998785024 modified "2023-10-16" @default.
- W1998785024 title "Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus <i>Stachybotrys chartarum</i> MXH-X73" @default.
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- W1998785024 doi "https://doi.org/10.1021/np400683h" @default.
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