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- W1998791609 abstract "Unmethylated CpG oligodinucleotides (CpG-ODN) flanked by specific bases found in bacterial DNA are known to stimulate innate immune responses. In this study, synthetic CpG-ODNs were evaluated for their in vitro stimulation of leukocyte and in vivo protection against Salmonella enteritidis (SE) in neonatal chickens. Our studies showed that CpG-ODN stimulated bactericidal activities, releasing granules (degranulation) and generating reactive oxygen species (oxidative burst), in chicken heterophils and up regulated nitric oxide production in chicken peripheral blood monocytes. When day-old chickens were given (i.p.) synthetic CpG-ODNs followed by oral challenge of SE, a significant reduction (p<0.05) of organ invasion by SE was observed in chickens pretreated with CpG-ODN containing the immunostimulatory GTCGTT motif. This CpG-OND also significantly reduced mortality of chickens with acute peritoneal infection of SE. Our study provides evidence that immunostimulatory CpG-ODN stimulated innate immune activities and enhanced the resistance to infectious pathogens in neonatal chickens." @default.
- W1998791609 created "2016-06-24" @default.
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- W1998791609 date "2005-01-01" @default.
- W1998791609 modified "2023-10-16" @default.
- W1998791609 title "In vitro activation of chicken leukocytes and in vivo protection against<i>Salmonella enteritidis</i>organ invasion and peritoneal<i>S. enteritidis</i>infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide" @default.
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- W1998791609 doi "https://doi.org/10.1016/j.femsim.2004.07.009" @default.
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