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- W1998794671 abstract "Summary: Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation–induced self‐sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15‐week period for the occurrence of interictal high‐amplitude low‐frequency (HALF) acitvity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. Conclusions: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology." @default.
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- W1998794671 date "2005-06-01" @default.
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- W1998794671 title "Spontaneous Epileptic Rats Show Changes in Sleep Architecture and Hypothalamic Pathology" @default.
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- W1998794671 doi "https://doi.org/10.1111/j.1528-1167.2005.63204.x" @default.
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