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- W1998797817 abstract "<i>To the Editor</i>.—Cimetidine-associated mental confusion is described in elderly patients, patients with renal or hepatic failure, or patients given high doses of the drug.<sup>1</sup>Moreover, cimetidine can delay the clearance of benzodiazepines that are administered to reduce mental confusion.<sup>2</sup>Patients treated with ranitidine instead have never shown mental impairment. <i>Report of a Case</i>.—A 57-year-old woman experienced mental confusion and coma while treated with large doses of cimetidine (4 g/day). Her condition was diagnosed as Zollinger-Ellison syndrome (ZES) with anastomotic peptic ulcer, on the basis of an increase in the blood gastrin level to 1,200 pg/mL after an intravenous injection of secretin (1 clinical unit/kg). Basal acid output was 6.8 mEq/hr. Celiac trunk and superior mesenteric arteriography showed a tumor stain of 3 to 4 cm in the head of the pancreas, but transhepatic portal catheterization did not show serious gastrin variations. Duodenopancreatectomy was performed, but postoperative" @default.
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- W1998797817 date "1983-02-01" @default.
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- W1998797817 title "Ranitidine Reverses Cimetidine-Induced Mental Confusion in a Patient With Zollinger-Ellison Syndrome" @default.
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- W1998797817 doi "https://doi.org/10.1001/archsurg.1983.01390020098022" @default.
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