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• W1998801919 abstract "Based on the crystal structures, three possible sequence determinants have been suggested as the cause of a 285 mV increase in reduction potential of the rubredoxin domain of rubrerythrin over rubredoxin by modulating the polar environment around the redox site. Here, electrostatic calculations of crystal structures of rubredoxin and rubrerythrin and molecular dynamics simulations of rubredoxin wild-type and mutants are used to elucidate the contributions to the increased reduction potential. Asn160 and His179 in rubrerythrin versus valines in rubredoxins are predicted to be the major contributors, as the polar side chains contribute significantly to the electrostatic potential in the redox site region. The mutant simulations show both side chains rotating on a nanosecond timescale between two conformations with different electrostatic contributions. Reduction also causes a change in the reduction energy that is consistent with a linear response due to the interesting mechanism of shifting the relative populations of the two conformations. In addition to this, a simulation of a triple mutant indicates the side-chain rotations are approximately anticorrelated so whereas one is in the high potential conformation, the other is in the low potential conformation. However, Ala176 in rubrerythrin versus a leucine in rubredoxin is not predicted to be a large contributor, because the solvent accessibility increases only slightly in mutant simulations and because it is buried in the interface of the rubrerythrin homodimer." @default.
• W1998801919 created "2016-06-24" @default.
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• W1998801919 date "2010-02-01" @default.
• W1998801919 modified "2023-10-12" @default.
• W1998801919 title "The Molecular Determinants of the Increased Reduction Potential of the Rubredoxin Domain of Rubrerythrin Relative to Rubredoxin" @default.
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• W1998801919 doi "https://doi.org/10.1016/j.bpj.2009.11.006" @default.
• W1998801919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2820635" @default.
• W1998801919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20159152" @default.
• W1998801919 hasPublicationYear "2010" @default.
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