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• W1998802012 abstract "General anesthetics are thought to depress the central nervous system (CNS) by acting at synapses; however, only a few studies have compared effects on axonal conduction with effects on synaptic responses using mammalian CNS preparations. The present study used glutamate receptor antagonists (CNQX/APV) or low calcium to block synaptic transmission, allowing Schaffer-collateral axon fiber volleys to be recorded from rat hippocampal brain slices. Since fiber volleys are compound action potentials, they provide a measure of axonal conduction in Schaffer-collateral fibers. Clinical concentrations of the inhalational anesthetic, halothane (1 rat MAC, 1.2 vol.%), produced an 18±2.3% depression of fiber volley amplitudes (mean±S.D.; p<0.001 ANOVA, n=10). Depression of action potential conduction accounted for ∼30% of the overall depression of synaptic transmission produced by halothane at this concentration. Halothane-induced fiber volley depression occurred with little change in conduction velocity, similar to the effect seen with decreased stimulus intensity, but significantly different from the decreased velocity produced by tetrodotoxin (100 nM, p<0.005). The results indicate that halothane can depress axonal conduction at clinically relevant concentrations and that this depression could contribute to the CNS depression that is associated with anesthesia." @default.
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• W1998802012 date "1998-06-01" @default.
• W1998802012 modified "2023-10-15" @default.
• W1998802012 title "Halothane depresses action potential conduction in hippocampal axons" @default.
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• W1998802012 doi "https://doi.org/10.1016/s0006-8993(98)00348-5" @default.
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