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• W1998804945 abstract "Polycyclic aromatic hydrocarbons (PAHs), wide-spread mutagenic and carcinogenic environmental pollutants, are consistently exposed to sunlight in the environment. The exposure causes structural change, resulting in the generation of a variety of photomodified products having different bioactivities compared with the parent compounds. In this study, we found that benzo[a]pyrene (BaP) exposed to solar-simulated light (SSL)-induced phosphorylation of histone H2AX (γ-H2AX), which was recently identified as an early event after the induction of DNA double strand breaks (DSBs). Although BaP itself did not produce γ-H2AX, SSL-exposed BaP significantly generated γ-H2AX depending on the period of exposure. Furthermore, we revealed that reactive oxygen species produced by the SSL-exposed BaP mainly contributed to the generation of γ-H2AX. The appearance of γ-H2AX means the induction of the most serious form of DNA damage, DSBs, suggesting the potential risk of carcinogenesis." @default.
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• W1998804945 date "2008-02-01" @default.
• W1998804945 modified "2023-09-28" @default.
• W1998804945 title "Solar-simulated light-exposed benzo[a]pyrene induces phosphorylation of histone H2AX" @default.
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• W1998804945 doi "https://doi.org/10.1016/j.mrgentox.2007.11.002" @default.
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