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• W1998822013 abstract "Tumor necrosis factor (TNF) inhibits and reverses differentiation of mouse adipogenic TA1 cells. We have found that TNF induces c-myc in a sustained manner in both preadipocytes and adipocytes; in contrast, serum induces c-myc transiently and only in preadipocytes. This TNF-mediated c-myc induction is not coupled with cell proliferation but is correlated with TNF-mediated inhibition of adipocyte differentiation. We prepared an inducible c-myc transformant of TA1 cells by transfection of the mouse c-myc gene under the control of the metallothionein-I promoter. These cells are unable to differentiate to adipocytes in the presence of Zn2+/Cd2+, and in differentiated TA1 cells, Zn2+/Cd2+ causes reduction of adipocyte-specific gene expression as does TNF. Lastly, exposure of TA1 cells to antisense c-myc oligonucleotide partially blocked the TNF-mediated reduction of adipocyte-specific gene expression. Thus, TNF-mediated c-myc expression is distinct in character from that involved in mitogenic responses but appears to play an important role in inhibition and reversal of adipocyte differentiation." @default.
• W1998822013 created "2016-06-24" @default.
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• W1998822013 creator A5078826648 @default.
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• W1998822013 date "1993-10-15" @default.
• W1998822013 modified "2023-10-14" @default.
• W1998822013 title "Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation." @default.
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• W1998822013 doi "https://doi.org/10.1073/pnas.90.20.9611" @default.
• W1998822013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47619" @default.
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