Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998825475> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1998825475 endingPage "22" @default.
- W1998825475 startingPage "15" @default.
- W1998825475 abstract "Bone cell activities are very important in bone remodeling. This study investigates the effects of lumbrokinase on bone cell activities in cultures. Moreover, a biodegradable composite (GGT) containing genipin-crosslinked gelatin and β-tricalcium phosphate was prepared to carry lumbrokinase (GGTLK). Rat calvarial bone defects were filled with GGT and GGTLK composites. Bone healing was monitored in vivo by bioluminescence imaging and micro-CT. Lumbrokinase was found to have a dose-dependent effect on bone cell activities. Low concentrations (<1μg/ml) of lumbrokinase increased the viability, total alkaline phosphatase activity and mobility of osteoblasts, the number of total calcified nodules and the expression of osteopontin and osteocalcin; however, they considerably reduced the total tartrate-resistant acid phosphatase activity of osteoclasts. IVIS images revealed a stronger fluorescent signal in GGTLK-treated animals than in GGT-treated animals. Micro-CT analysis revealed that GGTLK induced more new bone formation than did GGT. These observations suggest that lumbrokinase released from GGTLK composite can enhance bone tissue regeneration." @default.
- W1998825475 created "2016-06-24" @default.
- W1998825475 creator A5020975800 @default.
- W1998825475 creator A5024567332 @default.
- W1998825475 creator A5047866521 @default.
- W1998825475 creator A5073862148 @default.
- W1998825475 creator A5086017811 @default.
- W1998825475 date "2015-09-01" @default.
- W1998825475 modified "2023-10-16" @default.
- W1998825475 title "Porous gelatin/tricalcium phosphate/genipin composites containing lumbrokinase for bone repair" @default.
- W1998825475 cites W1977350434 @default.
- W1998825475 cites W1982859926 @default.
- W1998825475 cites W1983262945 @default.
- W1998825475 cites W1991360012 @default.
- W1998825475 cites W2007732288 @default.
- W1998825475 cites W2017569166 @default.
- W1998825475 cites W2023499955 @default.
- W1998825475 cites W2034546284 @default.
- W1998825475 cites W2042572711 @default.
- W1998825475 cites W2059690472 @default.
- W1998825475 cites W2081267619 @default.
- W1998825475 cites W2090277688 @default.
- W1998825475 cites W2100342527 @default.
- W1998825475 cites W2107533252 @default.
- W1998825475 cites W2157661459 @default.
- W1998825475 cites W2323872743 @default.
- W1998825475 cites W2404428172 @default.
- W1998825475 cites W85242181 @default.
- W1998825475 doi "https://doi.org/10.1016/j.bone.2015.04.034" @default.
- W1998825475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25933942" @default.
- W1998825475 hasPublicationYear "2015" @default.
- W1998825475 type Work @default.
- W1998825475 sameAs 1998825475 @default.
- W1998825475 citedByCount "23" @default.
- W1998825475 countsByYear W19988254752016 @default.
- W1998825475 countsByYear W19988254752017 @default.
- W1998825475 countsByYear W19988254752018 @default.
- W1998825475 countsByYear W19988254752019 @default.
- W1998825475 countsByYear W19988254752020 @default.
- W1998825475 countsByYear W19988254752021 @default.
- W1998825475 countsByYear W19988254752022 @default.
- W1998825475 countsByYear W19988254752023 @default.
- W1998825475 crossrefType "journal-article" @default.
- W1998825475 hasAuthorship W1998825475A5020975800 @default.
- W1998825475 hasAuthorship W1998825475A5024567332 @default.
- W1998825475 hasAuthorship W1998825475A5047866521 @default.
- W1998825475 hasAuthorship W1998825475A5073862148 @default.
- W1998825475 hasAuthorship W1998825475A5086017811 @default.
- W1998825475 hasConcept C105702510 @default.
- W1998825475 hasConcept C126322002 @default.
- W1998825475 hasConcept C131075544 @default.
- W1998825475 hasConcept C160160445 @default.
- W1998825475 hasConcept C170033053 @default.
- W1998825475 hasConcept C181199279 @default.
- W1998825475 hasConcept C185592680 @default.
- W1998825475 hasConcept C2778823387 @default.
- W1998825475 hasConcept C2779732960 @default.
- W1998825475 hasConcept C2780804394 @default.
- W1998825475 hasConcept C2781438746 @default.
- W1998825475 hasConcept C55493867 @default.
- W1998825475 hasConcept C71924100 @default.
- W1998825475 hasConcept C8337478 @default.
- W1998825475 hasConceptScore W1998825475C105702510 @default.
- W1998825475 hasConceptScore W1998825475C126322002 @default.
- W1998825475 hasConceptScore W1998825475C131075544 @default.
- W1998825475 hasConceptScore W1998825475C160160445 @default.
- W1998825475 hasConceptScore W1998825475C170033053 @default.
- W1998825475 hasConceptScore W1998825475C181199279 @default.
- W1998825475 hasConceptScore W1998825475C185592680 @default.
- W1998825475 hasConceptScore W1998825475C2778823387 @default.
- W1998825475 hasConceptScore W1998825475C2779732960 @default.
- W1998825475 hasConceptScore W1998825475C2780804394 @default.
- W1998825475 hasConceptScore W1998825475C2781438746 @default.
- W1998825475 hasConceptScore W1998825475C55493867 @default.
- W1998825475 hasConceptScore W1998825475C71924100 @default.
- W1998825475 hasConceptScore W1998825475C8337478 @default.
- W1998825475 hasFunder F4320321540 @default.
- W1998825475 hasFunder F4320322609 @default.
- W1998825475 hasLocation W19988254751 @default.
- W1998825475 hasLocation W19988254752 @default.
- W1998825475 hasOpenAccess W1998825475 @default.
- W1998825475 hasPrimaryLocation W19988254751 @default.
- W1998825475 hasRelatedWork W1972599893 @default.
- W1998825475 hasRelatedWork W1981582835 @default.
- W1998825475 hasRelatedWork W1988823632 @default.
- W1998825475 hasRelatedWork W2091683052 @default.
- W1998825475 hasRelatedWork W2143915146 @default.
- W1998825475 hasRelatedWork W2257842599 @default.
- W1998825475 hasRelatedWork W2369629293 @default.
- W1998825475 hasRelatedWork W2416805460 @default.
- W1998825475 hasRelatedWork W2943466263 @default.
- W1998825475 hasRelatedWork W3143224541 @default.
- W1998825475 hasVolume "78" @default.
- W1998825475 isParatext "false" @default.
- W1998825475 isRetracted "false" @default.
- W1998825475 magId "1998825475" @default.
- W1998825475 workType "article" @default.