Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998839295> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1998839295 endingPage "689" @default.
- W1998839295 startingPage "677" @default.
- W1998839295 abstract "Enhancement by anticoagulation of thrombolysis with infused or bolus-injected saruplase (r-scu-PA) has been studied using heparin and the thrombin inhibitor argatroban. In a rabbit femoral artery thrombosis model infusion of saruplase (3 - 12 mg/kg, 60 min) caused a dose-dependent thrombolysis. Reperfusion rate after infusion of 3 mg/kg saruplase alone was 3/6, reperfusion time 42 +/- 3 min and reocclusion rate 2/3; final patency rate at 120 min was 17%. Combination of 3 mg/kg saruplase with heparin (150 U/kg + 100 U/kg.hr i.v.; 5.3-fold PTT-prolongation) resulted in a reperfusion rate of 6/6 after a reperfusion time of 39 +/- 7 min; reocclusion rate was 3/6 and final patency rate was 50%. Argatroban (1 mg/kg + 3 mg/kg.hr i.v.; 2.3-fold PTT prolongation) in combination with saruplase resulted in a reperfusion rate of 6/6 after 26 +/- 5 min; no reocclusion occured and final patency rate was 100% (p less than 0.05 vs saruplase alone). Bolus injection of 6 mg/kg saruplase achieved reperfusion in 5/6 arteries after 15 +/- 3 min, but reocclusion rate was 4/5; final patency rate was 17%. Combination of bolus-injected saruplase with heparin resulted in a reperfusion rate of 4/6 after 8 +/- 3 min and no reocclusion occured; patency rate was 67%. With combination of argatroban and bolus-injected saruplase 6/6 arteries were reperfused after 8 +/- 3 min; reocclusion was prevented and final patency rate was 100% (p less than 0.05 vs saruplase-bolus alone). Systemic fibrinogenolysis was more pronounced with bolus injection than infusion of saruplase. The results indicate that arterial thrombolysis with saruplase can be enhanced by heparin and the thrombin inhibitor argatroban. The bolus injection of saruplase resulted in persistent reperfusion when simultaneous anticoagulation was performed. Despite less PTT prolongation, enhancement of saruplase-induced thrombolysis was more effective with argatroban than with heparin in rabbit femoral artery thrombosis." @default.
- W1998839295 created "2016-06-24" @default.
- W1998839295 creator A5045900735 @default.
- W1998839295 date "1991-12-01" @default.
- W1998839295 modified "2023-09-27" @default.
- W1998839295 title "Heparin and the thrombin inhibitor argatroban enhance fibrinolysis by infused or bolus-injected saruplase (r-scu-PA) in rabbit femoral artery thrombosis" @default.
- W1998839295 cites W1505957065 @default.
- W1998839295 cites W1978039741 @default.
- W1998839295 cites W1980123039 @default.
- W1998839295 cites W1986774920 @default.
- W1998839295 cites W1988171832 @default.
- W1998839295 cites W1990939561 @default.
- W1998839295 cites W1999674437 @default.
- W1998839295 cites W2025529818 @default.
- W1998839295 cites W2029782036 @default.
- W1998839295 cites W2032989095 @default.
- W1998839295 cites W2035307463 @default.
- W1998839295 cites W2042475987 @default.
- W1998839295 cites W2043352260 @default.
- W1998839295 cites W2053913287 @default.
- W1998839295 cites W2054251417 @default.
- W1998839295 cites W2067362956 @default.
- W1998839295 cites W2074542425 @default.
- W1998839295 cites W2395871307 @default.
- W1998839295 cites W2398543202 @default.
- W1998839295 cites W2408860493 @default.
- W1998839295 cites W2409231129 @default.
- W1998839295 cites W2417903862 @default.
- W1998839295 cites W52270747 @default.
- W1998839295 doi "https://doi.org/10.1016/0049-3848(91)90068-8" @default.
- W1998839295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1798957" @default.
- W1998839295 hasPublicationYear "1991" @default.
- W1998839295 type Work @default.
- W1998839295 sameAs 1998839295 @default.
- W1998839295 citedByCount "20" @default.
- W1998839295 crossrefType "journal-article" @default.
- W1998839295 hasAuthorship W1998839295A5045900735 @default.
- W1998839295 hasConcept C126322002 @default.
- W1998839295 hasConcept C141071460 @default.
- W1998839295 hasConcept C164705383 @default.
- W1998839295 hasConcept C2777292125 @default.
- W1998839295 hasConcept C2777557582 @default.
- W1998839295 hasConcept C2779581417 @default.
- W1998839295 hasConcept C2779612170 @default.
- W1998839295 hasConcept C2779723990 @default.
- W1998839295 hasConcept C2780868729 @default.
- W1998839295 hasConcept C42219234 @default.
- W1998839295 hasConcept C43376680 @default.
- W1998839295 hasConcept C500558357 @default.
- W1998839295 hasConcept C71924100 @default.
- W1998839295 hasConcept C89560881 @default.
- W1998839295 hasConceptScore W1998839295C126322002 @default.
- W1998839295 hasConceptScore W1998839295C141071460 @default.
- W1998839295 hasConceptScore W1998839295C164705383 @default.
- W1998839295 hasConceptScore W1998839295C2777292125 @default.
- W1998839295 hasConceptScore W1998839295C2777557582 @default.
- W1998839295 hasConceptScore W1998839295C2779581417 @default.
- W1998839295 hasConceptScore W1998839295C2779612170 @default.
- W1998839295 hasConceptScore W1998839295C2779723990 @default.
- W1998839295 hasConceptScore W1998839295C2780868729 @default.
- W1998839295 hasConceptScore W1998839295C42219234 @default.
- W1998839295 hasConceptScore W1998839295C43376680 @default.
- W1998839295 hasConceptScore W1998839295C500558357 @default.
- W1998839295 hasConceptScore W1998839295C71924100 @default.
- W1998839295 hasConceptScore W1998839295C89560881 @default.
- W1998839295 hasIssue "6" @default.
- W1998839295 hasLocation W19988392951 @default.
- W1998839295 hasLocation W19988392952 @default.
- W1998839295 hasOpenAccess W1998839295 @default.
- W1998839295 hasPrimaryLocation W19988392951 @default.
- W1998839295 hasRelatedWork W1715733843 @default.
- W1998839295 hasRelatedWork W17411602 @default.
- W1998839295 hasRelatedWork W2054728105 @default.
- W1998839295 hasRelatedWork W2067457927 @default.
- W1998839295 hasRelatedWork W2071655951 @default.
- W1998839295 hasRelatedWork W2348215793 @default.
- W1998839295 hasRelatedWork W2374512316 @default.
- W1998839295 hasRelatedWork W2410057693 @default.
- W1998839295 hasRelatedWork W2418664300 @default.
- W1998839295 hasRelatedWork W4294109446 @default.
- W1998839295 hasVolume "64" @default.
- W1998839295 isParatext "false" @default.
- W1998839295 isRetracted "false" @default.
- W1998839295 magId "1998839295" @default.
- W1998839295 workType "article" @default.