FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998862913> ?p ?o ?g. }

• W1998862913 endingPage "104" @default.
• W1998862913 startingPage "101" @default.
• W1998862913 abstract "We have successfully performed heart transplantation despite the most unfavourable risk factors for graft and patient survival: the presence of a high level of antibodies (Abs) against the donor's human leukocyte antigens (HLA) class I/II and blood group A1 antigens. The present study concerns post-transplant follow-up and characterization of donor reactive antibodies (DRA).Pre-transplant treatment consisted of mycophenolate mofetil (MMF), prednisolone, tacrolimus, intravenous immunoglobulin (IVIG), rituximab, protein-A immunoadsorption (PAIA) and per-operative plasma exchange. A standard triple-drug immunosuppressive protocol was used post-operatively. Abs were analyzed by the complement dependent cytotoxicity (CDC) test against donor and panel B/T cells and by flow cytometry (FlowPRA tests detecting isolated HLA class I/II antigens). Abs against the donor's erythrocytes were analyzed using a standard direct agglutination test for immunoglobulin M (IgM) Abs and a Bio-Rad AHG gel card test detecting IgG Abs and C3d.Pre-transplant treatment reduced Ab titers against the donor's lymphocytes from 128 to 16 and against the donor's blood group A1 antigen from 256 to 0. The patient was emergently transplanted with a heart from a blood group incompatible donor (A1 secretor to O). No hyperacute rejection was seen. DRA were present against all mismatched HLA class I and class II antigens at the time of transplantation; two of these DRA Abs disappeared within the first year post-transplant (anti-B62 and anti-DR4), one showed weakened reactivity (anti-A24) and one is still strongly reactive (anti-DQ3). The donor-specific CDC cross-match is still positive (titers 2 to 8). The level of panel reactive antibodies (PRA) remained unchanged from 6 months on post-transplant. Rising anti-A1 blood group Abs preceded the second rejection and were adsorbed by two blood group specific immunoadsorptions (Glycosorb)-ABO) and remained at a low level. IgM anti-A1 blood group Abs disappeared at 1 yr post-transplant and IgG Abs are still reactive with blood group A1 erythrocytes but at low titers (1 to 2).The patient is clinically well 2 years after heart transplantation despite the constant persistence of donor reactive IgG Abs against blood group A1 and HLA-DQ antigens. The reactivity of DRA against other mismatched HLA antigens disappeared or weakened during the follow-up period." @default.
• W1998862913 created "2016-06-24" @default.
• W1998862913 creator A5003782011 @default.
• W1998862913 creator A5053623853 @default.
• W1998862913 creator A5076477762 @default.
• W1998862913 date "2006-03-01" @default.
• W1998862913 modified "2023-10-10" @default.
• W1998862913 title "Heart transplantation across antibodies against human leukocyte antigens and blood group A1 antigen. Post-transplant follow-up of donor reactive antibodies." @default.
• W1998862913 cites W1966959110 @default.
• W1998862913 cites W1972873143 @default.
• W1998862913 cites W2028125915 @default.
• W1998862913 cites W2051629198 @default.
• W1998862913 cites W2054840487 @default.
• W1998862913 cites W2063458081 @default.
• W1998862913 cites W2081156317 @default.
• W1998862913 cites W2093207255 @default.
• W1998862913 cites W2125614435 @default.
• W1998862913 cites W4250734100 @default.
• W1998862913 doi "https://doi.org/10.1111/j.1399-3089.2006.00276.x" @default.
• W1998862913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16623800" @default.
• W1998862913 hasPublicationYear "2006" @default.
• W1998862913 type Work @default.
• W1998862913 sameAs 1998862913 @default.
• W1998862913 citedByCount "9" @default.
• W1998862913 countsByYear W19988629132012 @default.
• W1998862913 countsByYear W19988629132014 @default.
• W1998862913 countsByYear W19988629132015 @default.
• W1998862913 countsByYear W19988629132018 @default.
• W1998862913 crossrefType "journal-article" @default.
• W1998862913 hasAuthorship W1998862913A5003782011 @default.
• W1998862913 hasAuthorship W1998862913A5053623853 @default.
• W1998862913 hasAuthorship W1998862913A5076477762 @default.
• W1998862913 hasConcept C126322002 @default.
• W1998862913 hasConcept C147483822 @default.
• W1998862913 hasConcept C159654299 @default.
• W1998862913 hasConcept C188280979 @default.
• W1998862913 hasConcept C203014093 @default.
• W1998862913 hasConcept C2780653079 @default.
• W1998862913 hasConcept C2909675724 @default.
• W1998862913 hasConcept C2911091166 @default.
• W1998862913 hasConcept C64518967 @default.
• W1998862913 hasConcept C71924100 @default.
• W1998862913 hasConceptScore W1998862913C126322002 @default.
• W1998862913 hasConceptScore W1998862913C147483822 @default.
• W1998862913 hasConceptScore W1998862913C159654299 @default.
• W1998862913 hasConceptScore W1998862913C188280979 @default.
• W1998862913 hasConceptScore W1998862913C203014093 @default.
• W1998862913 hasConceptScore W1998862913C2780653079 @default.
• W1998862913 hasConceptScore W1998862913C2909675724 @default.
• W1998862913 hasConceptScore W1998862913C2911091166 @default.
• W1998862913 hasConceptScore W1998862913C64518967 @default.
• W1998862913 hasConceptScore W1998862913C71924100 @default.
• W1998862913 hasIssue "2" @default.
• W1998862913 hasLocation W19988629131 @default.
• W1998862913 hasLocation W19988629132 @default.
• W1998862913 hasOpenAccess W1998862913 @default.
• W1998862913 hasPrimaryLocation W19988629131 @default.
• W1998862913 hasRelatedWork W1509822413 @default.
• W1998862913 hasRelatedWork W2053502407 @default.
• W1998862913 hasRelatedWork W2062929029 @default.
• W1998862913 hasRelatedWork W2376315816 @default.
• W1998862913 hasRelatedWork W2379121469 @default.
• W1998862913 hasRelatedWork W2394331430 @default.
• W1998862913 hasRelatedWork W2507981663 @default.
• W1998862913 hasRelatedWork W2963322945 @default.
• W1998862913 hasRelatedWork W3030835380 @default.
• W1998862913 hasRelatedWork W3189567124 @default.
• W1998862913 hasVolume "13" @default.
• W1998862913 isParatext "false" @default.
• W1998862913 isRetracted "false" @default.
• W1998862913 magId "1998862913" @default.
• W1998862913 workType "article" @default.