Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998892433> ?p ?o ?g. }
- W1998892433 endingPage "7057" @default.
- W1998892433 startingPage "7051" @default.
- W1998892433 abstract "The nucleoside boranophosphates, having one of the nonbridging phosphate oxygens substituted with a borane (BH3) group, have shown potential therapeutical applications as aptamers, antisense agents, and antiviral prodrugs. An oxathiaphospholane approach, which does not require exocyclic amine protection of the nucleobase, has been successfully developed to efficiently synthesize 5‘-Pα-boranodiphosphates of 2‘-deoxythymidine, adenosine, guanosine, and uridine. The approach involves a key intermediate, the borane complex of nucleoside 5‘-O-1,3,2-oxathiaphospholane 16, that undergoes a ring-opening reaction catalyzed by 1,4-diazabicyclo[5.4.0]-undec-7-ene to form the protected nucleoside 5‘-Pα-boranodiphosphate 18. Treatment of 18 with ammonium hydroxide yielded diastereoisomeric mixtures of nucleoside 5‘-Pα-boranodiphosphates 5. This oxathiaphospholane approach ensures the availability of nucleoside 5‘-Pα-boranodiphosphate analogues needed for antiviral drug research." @default.
- W1998892433 created "2016-06-24" @default.
- W1998892433 creator A5064894644 @default.
- W1998892433 creator A5073070877 @default.
- W1998892433 date "2004-09-14" @default.
- W1998892433 modified "2023-10-16" @default.
- W1998892433 title "Convenient Synthesis of Nucleoside Borane Diphosphate Analogues: Deoxy- and Ribonucleoside 5‘-<i>P</i><sup>α</sup>-Boranodiphosphates" @default.
- W1998892433 cites W1423885963 @default.
- W1998892433 cites W1601059238 @default.
- W1998892433 cites W1678749080 @default.
- W1998892433 cites W1758820215 @default.
- W1998892433 cites W1797835435 @default.
- W1998892433 cites W1967273961 @default.
- W1998892433 cites W1977682255 @default.
- W1998892433 cites W1977991804 @default.
- W1998892433 cites W1982407847 @default.
- W1998892433 cites W1987524143 @default.
- W1998892433 cites W1989938481 @default.
- W1998892433 cites W1990957524 @default.
- W1998892433 cites W1991016296 @default.
- W1998892433 cites W1995626215 @default.
- W1998892433 cites W2006908561 @default.
- W1998892433 cites W2011752055 @default.
- W1998892433 cites W2012231281 @default.
- W1998892433 cites W2012864164 @default.
- W1998892433 cites W2013428743 @default.
- W1998892433 cites W2017436619 @default.
- W1998892433 cites W2020084384 @default.
- W1998892433 cites W2020889498 @default.
- W1998892433 cites W2023942953 @default.
- W1998892433 cites W2024637320 @default.
- W1998892433 cites W2030929533 @default.
- W1998892433 cites W2037020185 @default.
- W1998892433 cites W2037867633 @default.
- W1998892433 cites W2040355525 @default.
- W1998892433 cites W2044018182 @default.
- W1998892433 cites W2044143702 @default.
- W1998892433 cites W2045019638 @default.
- W1998892433 cites W2045719912 @default.
- W1998892433 cites W2054158439 @default.
- W1998892433 cites W2054401640 @default.
- W1998892433 cites W2056963499 @default.
- W1998892433 cites W2059676904 @default.
- W1998892433 cites W2068499273 @default.
- W1998892433 cites W2093220731 @default.
- W1998892433 cites W2116899406 @default.
- W1998892433 cites W2117772455 @default.
- W1998892433 cites W2121299852 @default.
- W1998892433 cites W2128066019 @default.
- W1998892433 cites W2132341663 @default.
- W1998892433 cites W2143181513 @default.
- W1998892433 cites W2153630542 @default.
- W1998892433 cites W2158496968 @default.
- W1998892433 cites W2162332760 @default.
- W1998892433 cites W2163015547 @default.
- W1998892433 cites W2165374724 @default.
- W1998892433 cites W2165611390 @default.
- W1998892433 cites W2166862191 @default.
- W1998892433 cites W2172799177 @default.
- W1998892433 cites W2178437809 @default.
- W1998892433 cites W2330806424 @default.
- W1998892433 cites W2338806373 @default.
- W1998892433 cites W2950766742 @default.
- W1998892433 cites W2951295501 @default.
- W1998892433 cites W2951352234 @default.
- W1998892433 cites W2951470777 @default.
- W1998892433 cites W4297901344 @default.
- W1998892433 cites W6714751 @default.
- W1998892433 cites W998812025 @default.
- W1998892433 doi "https://doi.org/10.1021/jo049094b" @default.
- W1998892433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15471452" @default.
- W1998892433 hasPublicationYear "2004" @default.
- W1998892433 type Work @default.
- W1998892433 sameAs 1998892433 @default.
- W1998892433 citedByCount "15" @default.
- W1998892433 countsByYear W19988924332012 @default.
- W1998892433 countsByYear W19988924332014 @default.
- W1998892433 countsByYear W19988924332015 @default.
- W1998892433 countsByYear W19988924332018 @default.
- W1998892433 countsByYear W19988924332019 @default.
- W1998892433 crossrefType "journal-article" @default.
- W1998892433 hasAuthorship W1998892433A5064894644 @default.
- W1998892433 hasAuthorship W1998892433A5073070877 @default.
- W1998892433 hasConcept C104317684 @default.
- W1998892433 hasConcept C108215921 @default.
- W1998892433 hasConcept C161790260 @default.
- W1998892433 hasConcept C178790620 @default.
- W1998892433 hasConcept C185592680 @default.
- W1998892433 hasConcept C21951064 @default.
- W1998892433 hasConcept C2776543447 @default.
- W1998892433 hasConcept C2776844798 @default.
- W1998892433 hasConcept C2776991684 @default.
- W1998892433 hasConcept C2777333352 @default.
- W1998892433 hasConcept C2777610669 @default.
- W1998892433 hasConcept C2777995097 @default.
- W1998892433 hasConcept C2778826510 @default.
- W1998892433 hasConcept C2781259782 @default.
- W1998892433 hasConcept C552990157 @default.