FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998907151> ?p ?o ?g. }

• W1998907151 endingPage "3096" @default.
• W1998907151 startingPage "3085" @default.
• W1998907151 abstract "Cyclic dinucleotides, including cyclic di-AMP (c-di-AMP), are known to be ubiquitous second messengers involved in bacterial signal transduction. However, no transcriptional regulator has been characterized as a c-di-AMP receptor/effector to date. In the present study, using a c-di-AMP/transcription factor binding screen, we identified Ms5346, a TetR family regulator in Mycobacterium smegmatis, as a c-di-AMP receptor in bacteria. Ms5346 could specifically bind c-di-AMP with K(d) of 2.3 ± 0.5 μM. Using EMSA and DNase I footprinting assays, c-di-AMP was found to stimulate the DNA binding activity of Ms5346 and to enhance its ability to protect its target DNA sequence. A conserved 14-bp palindromic motif was identified as the DNA-binding site for Ms5346. Further, Ms5346 was found to negatively regulate expression of three target genes including Ms5347 (encoding a major facilitator family transporter), Ms5348 (encoding a medium chain fatty acyl-CoA ligase), and Ms5696 (encoding a cold shock protein, CspA). Ms5346 is the first cyclic di-AMP receptor regulator to be identified in bacteria, and we have designated it as DarR. Our findings enhance our understanding of the function and regulatory mechanism of the second messenger c-di-AMP in bacteria." @default.
• W1998907151 created "2016-06-24" @default.
• W1998907151 creator A5023179600 @default.
• W1998907151 creator A5025032413 @default.
• W1998907151 creator A5078027349 @default.
• W1998907151 date "2013-02-01" @default.
• W1998907151 modified "2023-10-18" @default.
• W1998907151 title "DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor in Mycobacterium smegmatis" @default.
• W1998907151 cites W1675759131 @default.
• W1998907151 cites W1965389646 @default.
• W1998907151 cites W1984699600 @default.
• W1998907151 cites W2001078622 @default.
• W1998907151 cites W2003103534 @default.
• W1998907151 cites W2005096420 @default.
• W1998907151 cites W2022472102 @default.
• W1998907151 cites W2028434983 @default.
• W1998907151 cites W2031753305 @default.
• W1998907151 cites W2038564686 @default.
• W1998907151 cites W2039390702 @default.
• W1998907151 cites W2041189606 @default.
• W1998907151 cites W2043082285 @default.
• W1998907151 cites W2052262880 @default.
• W1998907151 cites W2056761870 @default.
• W1998907151 cites W2061036236 @default.
• W1998907151 cites W2067257071 @default.
• W1998907151 cites W2078905435 @default.
• W1998907151 cites W2080218311 @default.
• W1998907151 cites W2086085880 @default.
• W1998907151 cites W2089162014 @default.
• W1998907151 cites W2105028864 @default.
• W1998907151 cites W2105618126 @default.
• W1998907151 cites W2114434059 @default.
• W1998907151 cites W2115985525 @default.
• W1998907151 cites W2120077910 @default.
• W1998907151 cites W2125265960 @default.
• W1998907151 cites W2125504145 @default.
• W1998907151 cites W2136327827 @default.
• W1998907151 cites W2161621178 @default.
• W1998907151 cites W2165079807 @default.
• W1998907151 cites W2168421163 @default.
• W1998907151 doi "https://doi.org/10.1074/jbc.m112.428110" @default.
• W1998907151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561532" @default.
• W1998907151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23250743" @default.
• W1998907151 hasPublicationYear "2013" @default.
• W1998907151 type Work @default.
• W1998907151 sameAs 1998907151 @default.
• W1998907151 citedByCount "105" @default.
• W1998907151 countsByYear W19989071512013 @default.
• W1998907151 countsByYear W19989071512014 @default.
• W1998907151 countsByYear W19989071512015 @default.
• W1998907151 countsByYear W19989071512016 @default.
• W1998907151 countsByYear W19989071512017 @default.
• W1998907151 countsByYear W19989071512018 @default.
• W1998907151 countsByYear W19989071512019 @default.
• W1998907151 countsByYear W19989071512020 @default.
• W1998907151 countsByYear W19989071512021 @default.
• W1998907151 countsByYear W19989071512022 @default.
• W1998907151 countsByYear W19989071512023 @default.
• W1998907151 crossrefType "journal-article" @default.
• W1998907151 hasAuthorship W1998907151A5023179600 @default.
• W1998907151 hasAuthorship W1998907151A5025032413 @default.
• W1998907151 hasAuthorship W1998907151A5078027349 @default.
• W1998907151 hasBestOaLocation W19989071511 @default.
• W1998907151 hasConcept C104317684 @default.
• W1998907151 hasConcept C142724271 @default.
• W1998907151 hasConcept C153911025 @default.
• W1998907151 hasConcept C158448853 @default.
• W1998907151 hasConcept C2777204207 @default.
• W1998907151 hasConcept C2777274385 @default.
• W1998907151 hasConcept C2777975735 @default.
• W1998907151 hasConcept C2781069245 @default.
• W1998907151 hasConcept C55493867 @default.
• W1998907151 hasConcept C71924100 @default.
• W1998907151 hasConcept C86339819 @default.
• W1998907151 hasConcept C86803240 @default.
• W1998907151 hasConceptScore W1998907151C104317684 @default.
• W1998907151 hasConceptScore W1998907151C142724271 @default.
• W1998907151 hasConceptScore W1998907151C153911025 @default.
• W1998907151 hasConceptScore W1998907151C158448853 @default.
• W1998907151 hasConceptScore W1998907151C2777204207 @default.
• W1998907151 hasConceptScore W1998907151C2777274385 @default.
• W1998907151 hasConceptScore W1998907151C2777975735 @default.
• W1998907151 hasConceptScore W1998907151C2781069245 @default.
• W1998907151 hasConceptScore W1998907151C55493867 @default.
• W1998907151 hasConceptScore W1998907151C71924100 @default.
• W1998907151 hasConceptScore W1998907151C86339819 @default.
• W1998907151 hasConceptScore W1998907151C86803240 @default.
• W1998907151 hasIssue "5" @default.
• W1998907151 hasLocation W19989071511 @default.
• W1998907151 hasLocation W19989071512 @default.
• W1998907151 hasLocation W19989071513 @default.
• W1998907151 hasLocation W19989071514 @default.
• W1998907151 hasOpenAccess W1998907151 @default.
• W1998907151 hasPrimaryLocation W19989071511 @default.
• W1998907151 hasRelatedWork W1861767839 @default.
• W1998907151 hasRelatedWork W2012012967 @default.
• W1998907151 hasRelatedWork W2021296798 @default.
• W1998907151 hasRelatedWork W2049261534 @default.

• next