FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998908508> ?p ?o ?g. }

• W1998908508 endingPage "445" @default.
• W1998908508 startingPage "435" @default.
• W1998908508 abstract "A prominent tyrosine phosphorylated protein of 85 kDa (p85) was detected in highly proliferative sublines derived from the Jurkat T cell leukemia. We undertook a study to characterize the identity of this protein and its possible role in the hyperproliferative phenotypes observed. Using immunoblot and immunoprecipitation techniques, this protein was characterized as the p85 regulatory subunit of phosphatidylinositol 3-kinase. Cell proliferation and p85 tyrosine phosphorylation was not affected by tyrphostin AG-490, an inhibitor of Jak kinases, wortmannin or LY294002, inhibitors of the activity of the catalytic phosphatidylinositol 3-kinase subunit. Herbimycin-A and PP1, inhibitors of src-like protein tyrosine kinases, and genistein, a general tyrosine kinase inhibitor, inhibited p85 tyrosine phosphorylation and induced cell death in the sublines. PD98059, an inhibitor of Mek, inhibited cell growth of the sublines, but not that of the parental cells. It was concluded that tyrosine phosphorylation of p85 is associated with highly proliferative tumoral phenotypes, at least in T cell leukemias, independent of the phosphatidylinositol 3-kinase activity of the catalytic subunit." @default.
• W1998908508 created "2016-06-24" @default.
• W1998908508 creator A5017697662 @default.
• W1998908508 creator A5033737374 @default.
• W1998908508 creator A5046982945 @default.
• W1998908508 creator A5050926473 @default.
• W1998908508 creator A5059782439 @default.
• W1998908508 creator A5078936429 @default.
• W1998908508 creator A5082187879 @default.
• W1998908508 date "2000-04-01" @default.
• W1998908508 modified "2023-10-18" @default.
• W1998908508 title "Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia" @default.
• W1998908508 cites W1492026543 @default.
• W1998908508 cites W1529396499 @default.
• W1998908508 cites W1545503281 @default.
• W1998908508 cites W1573821584 @default.
• W1998908508 cites W1574471631 @default.
• W1998908508 cites W1575040416 @default.
• W1998908508 cites W1588962899 @default.
• W1998908508 cites W1598201397 @default.
• W1998908508 cites W1656644300 @default.
• W1998908508 cites W1980383883 @default.
• W1998908508 cites W1986694073 @default.
• W1998908508 cites W1988689320 @default.
• W1998908508 cites W2002127663 @default.
• W1998908508 cites W2002779187 @default.
• W1998908508 cites W2005529016 @default.
• W1998908508 cites W2016398041 @default.
• W1998908508 cites W2027361781 @default.
• W1998908508 cites W2035936653 @default.
• W1998908508 cites W2045819374 @default.
• W1998908508 cites W2054929655 @default.
• W1998908508 cites W2063117678 @default.
• W1998908508 cites W2063921652 @default.
• W1998908508 cites W2074571771 @default.
• W1998908508 cites W2077673188 @default.
• W1998908508 cites W2090895449 @default.
• W1998908508 cites W2092014913 @default.
• W1998908508 cites W2093571366 @default.
• W1998908508 cites W2124186695 @default.
• W1998908508 cites W2159072739 @default.
• W1998908508 cites W2293178816 @default.
• W1998908508 cites W2402700487 @default.
• W1998908508 cites W2404064356 @default.
• W1998908508 doi "https://doi.org/10.1016/s1357-2725(99)00142-9" @default.
• W1998908508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10762069" @default.
• W1998908508 hasPublicationYear "2000" @default.
• W1998908508 type Work @default.
• W1998908508 sameAs 1998908508 @default.
• W1998908508 citedByCount "32" @default.
• W1998908508 countsByYear W19989085082012 @default.
• W1998908508 countsByYear W19989085082013 @default.
• W1998908508 countsByYear W19989085082014 @default.
• W1998908508 countsByYear W19989085082015 @default.
• W1998908508 countsByYear W19989085082016 @default.
• W1998908508 countsByYear W19989085082017 @default.
• W1998908508 countsByYear W19989085082018 @default.
• W1998908508 countsByYear W19989085082020 @default.
• W1998908508 countsByYear W19989085082022 @default.
• W1998908508 countsByYear W19989085082023 @default.
• W1998908508 crossrefType "journal-article" @default.
• W1998908508 hasAuthorship W1998908508A5017697662 @default.
• W1998908508 hasAuthorship W1998908508A5033737374 @default.
• W1998908508 hasAuthorship W1998908508A5046982945 @default.
• W1998908508 hasAuthorship W1998908508A5050926473 @default.
• W1998908508 hasAuthorship W1998908508A5059782439 @default.
• W1998908508 hasAuthorship W1998908508A5078936429 @default.
• W1998908508 hasAuthorship W1998908508A5082187879 @default.
• W1998908508 hasConcept C101544691 @default.
• W1998908508 hasConcept C108636557 @default.
• W1998908508 hasConcept C11960822 @default.
• W1998908508 hasConcept C121608353 @default.
• W1998908508 hasConcept C153911025 @default.
• W1998908508 hasConcept C179464577 @default.
• W1998908508 hasConcept C203014093 @default.
• W1998908508 hasConcept C2776090121 @default.
• W1998908508 hasConcept C2777553839 @default.
• W1998908508 hasConcept C2778308172 @default.
• W1998908508 hasConcept C2778820342 @default.
• W1998908508 hasConcept C2780610907 @default.
• W1998908508 hasConcept C42362537 @default.
• W1998908508 hasConcept C502942594 @default.
• W1998908508 hasConcept C54355233 @default.
• W1998908508 hasConcept C55493867 @default.
• W1998908508 hasConcept C62112901 @default.
• W1998908508 hasConcept C62478195 @default.
• W1998908508 hasConcept C85528070 @default.
• W1998908508 hasConcept C86803240 @default.
• W1998908508 hasConcept C8891405 @default.
• W1998908508 hasConcept C95444343 @default.
• W1998908508 hasConceptScore W1998908508C101544691 @default.
• W1998908508 hasConceptScore W1998908508C108636557 @default.
• W1998908508 hasConceptScore W1998908508C11960822 @default.
• W1998908508 hasConceptScore W1998908508C121608353 @default.
• W1998908508 hasConceptScore W1998908508C153911025 @default.
• W1998908508 hasConceptScore W1998908508C179464577 @default.
• W1998908508 hasConceptScore W1998908508C203014093 @default.
• W1998908508 hasConceptScore W1998908508C2776090121 @default.

• next