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• W1998917046 endingPage "541" @default.
• W1998917046 startingPage "521" @default.
• W1998917046 abstract "Vaccinia virus, the prototype of the Poxviridae, is a large DNA virus which replicates in the cytoplasm of the host cell. The assembly pathway of vaccinia virus displays several unique features, such as the production of two structurally distinct, infectious forms. One of these, termed intracellular naked virus (INV), remains cells associated while the other, termed extracellular enveloped virus (EEV), is released from the cell. In addition, it has long been believed that INVs acquire their lipid envelopes by a unique example of de novo membrane biogenesis. To examine the structure and assembly of vaccinia virus we have used immunoelectron microscopy using antibodies to proteins of different subcellular compartments as well as a phospholipid analysis of purified INV and EEV. Our data are not consistent with the de novo model of viral membrane synthesis but rather argue that the vaccinia virus DNA becomes enwrapped by a membrane cisterna derived from the intermediate compartment between the ER and the Golgi stacks, thus acquiring two membranes in one step. Phospholipid analysis of purified INV supports its derivation from an early biosynthetic compartment. This unique assembly process is repeated once more when the INV becomes enwrapped by an additional membrane cisterna, in agreement with earlier reports. The available data suggest that after fusion between the outer envelope and the plasma membrane, mature EEV is released from the cell." @default.
• W1998917046 created "2016-06-24" @default.
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• W1998917046 date "1993-05-01" @default.
• W1998917046 modified "2023-10-18" @default.
• W1998917046 title "Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks." @default.
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• W1998917046 doi "https://doi.org/10.1083/jcb.121.3.521" @default.
• W1998917046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2119557" @default.
• W1998917046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8486734" @default.
• W1998917046 hasPublicationYear "1993" @default.
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