FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998922123> ?p ?o ?g. }

• W1998922123 endingPage "58" @default.
• W1998922123 startingPage "52" @default.
• W1998922123 abstract "Mizoribine, an imidazole nucleoside, is an inhibitor of purine synthesis and has been used as an orally available immunosuppressive agent in human renal transplantation. In the present study, the intestinal absorption of mizoribine was characterized by examining the contribution of concentrative nucleoside transporters (CNT1, CNT2) in rats. When mizoribine was administered orally in conscious rats, the bioavailability of mizoribine estimated by urinary excretion percentage of unchanged mizoribine was a dose dependent: 53.1+/-6.0% at 5 mg/kg and 24.0+/-5.1% at 20 mg/kg. In in-situ loop studies, the disappearance rate, or absorption rate, of mizoribine from the intestinal lumen was comparable between 1 and 5 mg/kg, but significantly lower at 25 mg/kg. Coadministration of adenosine (a substrate of both CNT1 and CNT2), thymidine (a CNT1 substrate) and inosine (a CNT2 substrate) significantly suppressed the intestinal mizoribine absorption, depending on the nucleoside concentrations coadministered. Gemcitabine (a pyrimidine nucleoside analogue, a CNT1 substrate) and ribavirin (a purine nucleoside analog, a CNT2 substrate) also significantly suppressed the mizoribine intestinal absorption. Bile salts such as sodium cholate and sodium glycocholate (10 mM) also significantly suppressed the intestinal mizoribine absorption, but not ribavirin absorption. Mizoribine is an amphoteric compound, however, the suppression of intestinal absorption by bile salts was not ascribed to the electrostatic interaction or micellar formation between mizoribine and bile salts. In conclusion, the intestinal absorption of mizoribine is mediated by CNT1 and CNT2, and nucleoside-derived drugs such as gemcitabine and ribavirin can suppress the intestinal absorption of mizoribine. Bile salts such as sodium glycocholate were also found to cause interaction with mizoribine." @default.
• W1998922123 created "2016-06-24" @default.
• W1998922123 creator A5035196333 @default.
• W1998922123 creator A5039978322 @default.
• W1998922123 creator A5050960065 @default.
• W1998922123 creator A5089046975 @default.
• W1998922123 date "2008-05-01" @default.
• W1998922123 modified "2023-10-03" @default.
• W1998922123 title "Characterization of intestinal absorption of mizoribine mediated by concentrative nucleoside transporters in rats" @default.
• W1998922123 cites W1572461322 @default.
• W1998922123 cites W1967675162 @default.
• W1998922123 cites W1977108776 @default.
• W1998922123 cites W1982153288 @default.
• W1998922123 cites W1983635695 @default.
• W1998922123 cites W1990291419 @default.
• W1998922123 cites W1993258772 @default.
• W1998922123 cites W1996039241 @default.
• W1998922123 cites W1998058209 @default.
• W1998922123 cites W1999794948 @default.
• W1998922123 cites W2004026535 @default.
• W1998922123 cites W2012853846 @default.
• W1998922123 cites W2016971348 @default.
• W1998922123 cites W2026696520 @default.
• W1998922123 cites W2048312836 @default.
• W1998922123 cites W2051577815 @default.
• W1998922123 cites W2058328523 @default.
• W1998922123 cites W2066528218 @default.
• W1998922123 cites W2069333940 @default.
• W1998922123 cites W2076443831 @default.
• W1998922123 cites W2083347658 @default.
• W1998922123 cites W2101017561 @default.
• W1998922123 cites W2149200961 @default.
• W1998922123 cites W2160930473 @default.
• W1998922123 cites W225101619 @default.
• W1998922123 cites W2335523929 @default.
• W1998922123 cites W2951505772 @default.
• W1998922123 doi "https://doi.org/10.1016/j.ejphar.2008.02.043" @default.
• W1998922123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18371949" @default.
• W1998922123 hasPublicationYear "2008" @default.
• W1998922123 type Work @default.
• W1998922123 sameAs 1998922123 @default.
• W1998922123 citedByCount "21" @default.
• W1998922123 countsByYear W19989221232012 @default.
• W1998922123 countsByYear W19989221232013 @default.
• W1998922123 countsByYear W19989221232015 @default.
• W1998922123 countsByYear W19989221232016 @default.
• W1998922123 countsByYear W19989221232017 @default.
• W1998922123 countsByYear W19989221232018 @default.
• W1998922123 countsByYear W19989221232019 @default.
• W1998922123 countsByYear W19989221232020 @default.
• W1998922123 countsByYear W19989221232021 @default.
• W1998922123 countsByYear W19989221232023 @default.
• W1998922123 crossrefType "journal-article" @default.
• W1998922123 hasAuthorship W1998922123A5035196333 @default.
• W1998922123 hasAuthorship W1998922123A5039978322 @default.
• W1998922123 hasAuthorship W1998922123A5050960065 @default.
• W1998922123 hasAuthorship W1998922123A5089046975 @default.
• W1998922123 hasConcept C126322002 @default.
• W1998922123 hasConcept C185592680 @default.
• W1998922123 hasConcept C2776543447 @default.
• W1998922123 hasConcept C2777882293 @default.
• W1998922123 hasConcept C55493867 @default.
• W1998922123 hasConcept C71924100 @default.
• W1998922123 hasConcept C86803240 @default.
• W1998922123 hasConcept C98274493 @default.
• W1998922123 hasConceptScore W1998922123C126322002 @default.
• W1998922123 hasConceptScore W1998922123C185592680 @default.
• W1998922123 hasConceptScore W1998922123C2776543447 @default.
• W1998922123 hasConceptScore W1998922123C2777882293 @default.
• W1998922123 hasConceptScore W1998922123C55493867 @default.
• W1998922123 hasConceptScore W1998922123C71924100 @default.
• W1998922123 hasConceptScore W1998922123C86803240 @default.
• W1998922123 hasConceptScore W1998922123C98274493 @default.
• W1998922123 hasIssue "1-3" @default.
• W1998922123 hasLocation W19989221231 @default.
• W1998922123 hasLocation W19989221232 @default.
• W1998922123 hasOpenAccess W1998922123 @default.
• W1998922123 hasPrimaryLocation W19989221231 @default.
• W1998922123 hasRelatedWork W2024286208 @default.
• W1998922123 hasRelatedWork W2048009242 @default.
• W1998922123 hasRelatedWork W2055837608 @default.
• W1998922123 hasRelatedWork W2074030109 @default.
• W1998922123 hasRelatedWork W2142257732 @default.
• W1998922123 hasRelatedWork W2323650234 @default.
• W1998922123 hasRelatedWork W2605011488 @default.
• W1998922123 hasRelatedWork W2607273186 @default.
• W1998922123 hasRelatedWork W2949105847 @default.
• W1998922123 hasRelatedWork W2953206624 @default.
• W1998922123 hasVolume "586" @default.
• W1998922123 isParatext "false" @default.
• W1998922123 isRetracted "false" @default.
• W1998922123 magId "1998922123" @default.
• W1998922123 workType "article" @default.