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- W1998926649 abstract "Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A. marginale strains based on N-terminal tandem repeats and a 5′-UTR microsatellite located in the msp1a gene. The MSP1a tandem repeats contain immune relevant elements and functional domains that bind to bovine erythrocytes and tick cells, thus providing information about the evolution of host-pathogen and vector-pathogen interactions. Here we propose one nomenclature for A. marginale strain classification based on MSP1a. All tandem repeats among A. marginale strains were classified and the amino acid variability/frequency in each position was determined. The sequence variation at immunodominant B cell epitopes was determined and the secondary (2D) structure of the tandem repeats was modeled. A total of 224 different strains of A. marginale were classified, showing 11 genotypes based on the 5′-UTR microsatellite and 193 different tandem repeats with high amino acid variability per position. Our results showed phylogenetic correlation between MSP1a sequence, secondary structure, B-cell epitope composition and tick transmissibility of A. marginale strains. The analysis of MSP1a sequences provides relevant information about the biology of A. marginale to design vaccines with a cross-protective capacity based on MSP1a B-cell epitopes." @default.
- W1998926649 created "2016-06-24" @default.
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- W1998926649 date "2013-06-11" @default.
- W1998926649 modified "2023-10-16" @default.
- W1998926649 title "Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis" @default.
- W1998926649 cites W1521650410 @default.
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- W1998926649 cites W1953990936 @default.
- W1998926649 cites W1963957860 @default.
- W1998926649 cites W1971033663 @default.
- W1998926649 cites W1972642489 @default.
- W1998926649 cites W1976036478 @default.
- W1998926649 cites W1978528421 @default.
- W1998926649 cites W1980308658 @default.
- W1998926649 cites W1981024135 @default.
- W1998926649 cites W1983227647 @default.
- W1998926649 cites W1986186850 @default.
- W1998926649 cites W1989743311 @default.
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- W1998926649 cites W1993735906 @default.
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- W1998926649 cites W2026461769 @default.
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- W1998926649 doi "https://doi.org/10.1371/journal.pone.0065243" @default.
- W1998926649 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3679145" @default.
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- W1998926649 hasPublicationYear "2013" @default.
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