FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998944669> ?p ?o ?g. }

• W1998944669 endingPage "831" @default.
• W1998944669 startingPage "822" @default.
• W1998944669 abstract "Human sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase that participates in cell death/survival, senescence and metabolism. Although its substrates are well characterized, no direct regulators have been defined. Here, we show that SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor (RAR). Binding assays indicated that SKIP interacts with RAR in a RA-dependent manner, through a region that overlaps the binding site for SIRT1. SKIP augmented the transcriptional activation activity of RAR by cooperating with SRC-1, and SIRT1 suppressed SKIP/SRC-1-enhanced RAR transactivation activity. The suppression was dependent on the deacetylase activity of SIRT1 and was enhanced by a SIRT1 activator, resveratrol. In contrast, the suppression was relieved by SIRT1 knockdown, overexpression of SKIP and treatment with a SIRT1 inhibitor, splitomicin. Upon SKIP overexpression, the recruitment of SIRT1 to the endogenous RARβ2 promoter was severely impaired, and SKIP was recruited to the promoter instead. Finally, resveratrol treatment inhibited RA-induced neuronal differentiation of P19 cells, accompanied by reductions in the neuronal marker nestin and a RAR target gene, RARβ2. This inhibition was relieved by either knockdown of SIRT1 or overexpression of SKIP. These data suggest that SIRT1 and SKIP play reciprocal roles in the regulation of RAR activity, which is implicated in the regulation of RA-induced neuronal differentiation of P19 cells." @default.
• W1998944669 created "2016-06-24" @default.
• W1998944669 creator A5013520002 @default.
• W1998944669 creator A5025810417 @default.
• W1998944669 creator A5037168895 @default.
• W1998944669 creator A5039880005 @default.
• W1998944669 creator A5047072484 @default.
• W1998944669 creator A5058648032 @default.
• W1998944669 creator A5063335685 @default.
• W1998944669 date "2009-11-24" @default.
• W1998944669 modified "2023-10-12" @default.
• W1998944669 title "Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells" @default.
• W1998944669 cites W1964448607 @default.
• W1998944669 cites W1969346281 @default.
• W1998944669 cites W1969408132 @default.
• W1998944669 cites W1975522366 @default.
• W1998944669 cites W1995095187 @default.
• W1998944669 cites W1999673859 @default.
• W1998944669 cites W2003906235 @default.
• W1998944669 cites W2010052865 @default.
• W1998944669 cites W2012147370 @default.
• W1998944669 cites W2012753961 @default.
• W1998944669 cites W2018492629 @default.
• W1998944669 cites W2019757555 @default.
• W1998944669 cites W2026561146 @default.
• W1998944669 cites W2027815400 @default.
• W1998944669 cites W2040711515 @default.
• W1998944669 cites W2049385704 @default.
• W1998944669 cites W2052572393 @default.
• W1998944669 cites W2054447845 @default.
• W1998944669 cites W2069752613 @default.
• W1998944669 cites W2072374770 @default.
• W1998944669 cites W2074740541 @default.
• W1998944669 cites W2078746985 @default.
• W1998944669 cites W2079042280 @default.
• W1998944669 cites W2084707133 @default.
• W1998944669 cites W2086576919 @default.
• W1998944669 cites W2086908959 @default.
• W1998944669 cites W2094807579 @default.
• W1998944669 cites W2097411118 @default.
• W1998944669 cites W2107372115 @default.
• W1998944669 cites W2109784331 @default.
• W1998944669 cites W2124595934 @default.
• W1998944669 cites W2124898423 @default.
• W1998944669 cites W2130532370 @default.
• W1998944669 cites W2139449514 @default.
• W1998944669 cites W2140925956 @default.
• W1998944669 cites W2152101492 @default.
• W1998944669 cites W2155972116 @default.
• W1998944669 cites W2157416168 @default.
• W1998944669 cites W2170498202 @default.
• W1998944669 cites W2171391341 @default.
• W1998944669 doi "https://doi.org/10.1093/nar/gkp1056" @default.
• W1998944669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817470" @default.
• W1998944669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19934264" @default.
• W1998944669 hasPublicationYear "2009" @default.
• W1998944669 type Work @default.
• W1998944669 sameAs 1998944669 @default.
• W1998944669 citedByCount "32" @default.
• W1998944669 countsByYear W19989446692012 @default.
• W1998944669 countsByYear W19989446692013 @default.
• W1998944669 countsByYear W19989446692014 @default.
• W1998944669 countsByYear W19989446692015 @default.
• W1998944669 countsByYear W19989446692016 @default.
• W1998944669 countsByYear W19989446692017 @default.
• W1998944669 countsByYear W19989446692018 @default.
• W1998944669 countsByYear W19989446692019 @default.
• W1998944669 countsByYear W19989446692020 @default.
• W1998944669 countsByYear W19989446692021 @default.
• W1998944669 countsByYear W19989446692022 @default.
• W1998944669 crossrefType "journal-article" @default.
• W1998944669 hasAuthorship W1998944669A5013520002 @default.
• W1998944669 hasAuthorship W1998944669A5025810417 @default.
• W1998944669 hasAuthorship W1998944669A5037168895 @default.
• W1998944669 hasAuthorship W1998944669A5039880005 @default.
• W1998944669 hasAuthorship W1998944669A5047072484 @default.
• W1998944669 hasAuthorship W1998944669A5058648032 @default.
• W1998944669 hasAuthorship W1998944669A5063335685 @default.
• W1998944669 hasBestOaLocation W19989446691 @default.
• W1998944669 hasConcept C104317684 @default.
• W1998944669 hasConcept C120197328 @default.
• W1998944669 hasConcept C127561419 @default.
• W1998944669 hasConcept C1292079 @default.
• W1998944669 hasConcept C148738053 @default.
• W1998944669 hasConcept C150194340 @default.
• W1998944669 hasConcept C153911025 @default.
• W1998944669 hasConcept C170493617 @default.
• W1998944669 hasConcept C173396325 @default.
• W1998944669 hasConcept C181199279 @default.
• W1998944669 hasConcept C186310378 @default.
• W1998944669 hasConcept C2776536020 @default.
• W1998944669 hasConcept C2781121885 @default.
• W1998944669 hasConcept C502942594 @default.
• W1998944669 hasConcept C55493867 @default.
• W1998944669 hasConcept C75520062 @default.
• W1998944669 hasConcept C77445288 @default.
• W1998944669 hasConcept C86339819 @default.
• W1998944669 hasConcept C86803240 @default.

• next