Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998959197> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1998959197 endingPage "64" @default.
- W1998959197 startingPage "50" @default.
- W1998959197 abstract "Murine peritoneal macrophages primed in vivo by trehalose dimycolate (TDM) express cytostatic activity against tumor cells after treatment in vitro with; 10 mg/ml lipopolysaccharide (LPS) during a 4-hr period (activation step). There is a strict correlation (P <0.0001) between acquisition of antitumoral activity and induction of NO synthase quantified by its end products citrulline and NO-2. LPS also stimulates the release of cyclooxygenase products which exert a retroinhibitory action on NO synthase and cytostatic activities, as judged by an increase of both parameters by indomethacin (1 μM) and a decrease by externally added PGE2 (1 μM). LPS increases cellular and extracellular cAMP levels through an indomethacin-sensitive pathway, pointing to cAMP as a second messenger in the retroinhibitory action of LPS-induced prostaglandins. In fact, the addition of 8-bromo-cAMP or of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine during the activation step decreases NO synthase activity; however, at the same time these drugs increase the apparent efficiency of NO as an antitumor agent." @default.
- W1998959197 created "2016-06-24" @default.
- W1998959197 creator A5059865909 @default.
- W1998959197 creator A5073472130 @default.
- W1998959197 creator A5081357911 @default.
- W1998959197 date "1993-06-01" @default.
- W1998959197 modified "2023-09-25" @default.
- W1998959197 title "LPS-Induced Activation of Primed Murine Peritoneal Macrophages Is Modulated by Prostaglandins and Cyclic Nucleotides" @default.
- W1998959197 doi "https://doi.org/10.1006/cimm.1993.1135" @default.
- W1998959197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7685661" @default.
- W1998959197 hasPublicationYear "1993" @default.
- W1998959197 type Work @default.
- W1998959197 sameAs 1998959197 @default.
- W1998959197 citedByCount "44" @default.
- W1998959197 countsByYear W19989591972013 @default.
- W1998959197 countsByYear W19989591972014 @default.
- W1998959197 countsByYear W19989591972015 @default.
- W1998959197 countsByYear W19989591972018 @default.
- W1998959197 countsByYear W19989591972020 @default.
- W1998959197 crossrefType "journal-article" @default.
- W1998959197 hasAuthorship W1998959197A5059865909 @default.
- W1998959197 hasAuthorship W1998959197A5073472130 @default.
- W1998959197 hasAuthorship W1998959197A5081357911 @default.
- W1998959197 hasConcept C112243037 @default.
- W1998959197 hasConcept C134018914 @default.
- W1998959197 hasConcept C150903083 @default.
- W1998959197 hasConcept C163235415 @default.
- W1998959197 hasConcept C181199279 @default.
- W1998959197 hasConcept C202751555 @default.
- W1998959197 hasConcept C207001950 @default.
- W1998959197 hasConcept C2777622882 @default.
- W1998959197 hasConcept C2777956040 @default.
- W1998959197 hasConcept C2778754761 @default.
- W1998959197 hasConcept C2779689624 @default.
- W1998959197 hasConcept C28406088 @default.
- W1998959197 hasConcept C55493867 @default.
- W1998959197 hasConcept C62826618 @default.
- W1998959197 hasConcept C86803240 @default.
- W1998959197 hasConcept C98274493 @default.
- W1998959197 hasConceptScore W1998959197C112243037 @default.
- W1998959197 hasConceptScore W1998959197C134018914 @default.
- W1998959197 hasConceptScore W1998959197C150903083 @default.
- W1998959197 hasConceptScore W1998959197C163235415 @default.
- W1998959197 hasConceptScore W1998959197C181199279 @default.
- W1998959197 hasConceptScore W1998959197C202751555 @default.
- W1998959197 hasConceptScore W1998959197C207001950 @default.
- W1998959197 hasConceptScore W1998959197C2777622882 @default.
- W1998959197 hasConceptScore W1998959197C2777956040 @default.
- W1998959197 hasConceptScore W1998959197C2778754761 @default.
- W1998959197 hasConceptScore W1998959197C2779689624 @default.
- W1998959197 hasConceptScore W1998959197C28406088 @default.
- W1998959197 hasConceptScore W1998959197C55493867 @default.
- W1998959197 hasConceptScore W1998959197C62826618 @default.
- W1998959197 hasConceptScore W1998959197C86803240 @default.
- W1998959197 hasConceptScore W1998959197C98274493 @default.
- W1998959197 hasIssue "1" @default.
- W1998959197 hasLocation W19989591971 @default.
- W1998959197 hasLocation W19989591972 @default.
- W1998959197 hasOpenAccess W1998959197 @default.
- W1998959197 hasPrimaryLocation W19989591971 @default.
- W1998959197 hasRelatedWork W1045377105 @default.
- W1998959197 hasRelatedWork W1543286038 @default.
- W1998959197 hasRelatedWork W1903930571 @default.
- W1998959197 hasRelatedWork W1990567068 @default.
- W1998959197 hasRelatedWork W2043588095 @default.
- W1998959197 hasRelatedWork W2059930144 @default.
- W1998959197 hasRelatedWork W2089747387 @default.
- W1998959197 hasRelatedWork W2091494117 @default.
- W1998959197 hasRelatedWork W2154746436 @default.
- W1998959197 hasRelatedWork W3178871832 @default.
- W1998959197 hasVolume "149" @default.
- W1998959197 isParatext "false" @default.
- W1998959197 isRetracted "false" @default.
- W1998959197 magId "1998959197" @default.
- W1998959197 workType "article" @default.