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- W1998959310 abstract "Abstract Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) is a crucial cytokine for establishing pregnancy. It has been demonstrated previously in rats that sleep increases during early pregnancy and that centrally administered GM‐CSF promotes both rapid eye movement (REM) and non‐REM sleep. Therefore, whether GM‐CSF is involved in pregnancy‐enhanced sleep was investigated using the anti‐GM‐CSF antibody. Female rats received an intracerebroventricular infusion of either anti‐GM‐CSF or control IgG (10 μg each) for four nights from the first day of pregnancy (PD1–PD4). Although sleep amounts on PD1 were not affected, anti‐GM‐CSF decreased non‐REM and REM sleep significantly during PD2–PD4 compared with the control baseline of the IgG group. The results demonstrated that anti‐GM‐CSF treatment suppresses pregnancy‐enhanced sleep, suggesting that GM‐CSF contributes to sleep regulation during pregnancy." @default.
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- W1998959310 date "2002-06-01" @default.
- W1998959310 modified "2023-10-18" @default.
- W1998959310 title "Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep" @default.
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- W1998959310 doi "https://doi.org/10.1046/j.1440-1819.2002.00968.x" @default.
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