FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998959547> ?p ?o ?g. }

• W1998959547 endingPage "255" @default.
• W1998959547 startingPage "251" @default.
• W1998959547 abstract "Sepsis is the leading cause of death in critically ill patients. Today, around 60% of all cases of sepsis are caused by Gram-negative bacteria. The cell wall component lipopoly-saccharide (LPS) is the main initiator of the cascade of cellular reactions in Gram-negative infections. The core receptors for LPS are toll-like receptor 4 (TLR4), MD-2 and CD14. Attempts have been made to antagonize the toxic effect of endotoxin using monoclonal antibodies against CD14 and synthetic lipopolysaccharides but there is as yet no effective treatment for septic syndrome. Here, we describe an inhibitory effect of a phosphatidylethanolamine derivative, PE-DTPA (phosphatidylethanolamine diethyl-enetriaminepentaacetate) on LPS recognition. PE-DTPA bound strongly to CD14 (K ( d ), 9.52 x 10(-8) M). It dose dependency inhibited LPS-mediated activation of human myeloid cells, mouse macrophage cells and human whole blood as measured by the production of tumor necrosis factor-a (TNF-alpha) and nitric oxide, whereas other phospho-lipids including phosphatidylserine and phosphatidylethanolamine had little effect. PE-DTPA also inhibited transcription dependent on NF-kappaB activation when it was added together with LPS, and it rescued LPS-primed mice from septic death. These results suggest that PE-DTPA is a potent antagonist of LPS, and that it acts by competing for binding to CD14." @default.
• W1998959547 created "2016-06-24" @default.
• W1998959547 creator A5052707524 @default.
• W1998959547 creator A5058466227 @default.
• W1998959547 creator A5059691183 @default.
• W1998959547 creator A5060968872 @default.
• W1998959547 creator A5087456386 @default.
• W1998959547 date "2009-02-01" @default.
• W1998959547 modified "2023-09-23" @default.
• W1998959547 title "Inhibitory effect of a phosphatidyl ethanolamine derivative on LPS-induced sepsis" @default.
• W1998959547 cites W11333915 @default.
• W1998959547 cites W1658974469 @default.
• W1998959547 cites W1966599176 @default.
• W1998959547 cites W1986974750 @default.
• W1998959547 cites W1991109223 @default.
• W1998959547 cites W2004091477 @default.
• W1998959547 cites W2029157767 @default.
• W1998959547 cites W2032798581 @default.
• W1998959547 cites W2037533969 @default.
• W1998959547 cites W2049927822 @default.
• W1998959547 cites W2065053912 @default.
• W1998959547 cites W2093355099 @default.
• W1998959547 cites W2112799653 @default.
• W1998959547 cites W2113828544 @default.
• W1998959547 cites W2149167276 @default.
• W1998959547 cites W2149697611 @default.
• W1998959547 cites W2171765848 @default.
• W1998959547 cites W4234317413 @default.
• W1998959547 doi "https://doi.org/10.1007/s10059-009-0049-4" @default.
• W1998959547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19277509" @default.
• W1998959547 hasPublicationYear "2009" @default.
• W1998959547 type Work @default.
• W1998959547 sameAs 1998959547 @default.
• W1998959547 citedByCount "11" @default.
• W1998959547 countsByYear W19989595472012 @default.
• W1998959547 countsByYear W19989595472013 @default.
• W1998959547 countsByYear W19989595472015 @default.
• W1998959547 countsByYear W19989595472016 @default.
• W1998959547 countsByYear W19989595472017 @default.
• W1998959547 countsByYear W19989595472018 @default.
• W1998959547 countsByYear W19989595472019 @default.
• W1998959547 countsByYear W19989595472020 @default.
• W1998959547 crossrefType "journal-article" @default.
• W1998959547 hasAuthorship W1998959547A5052707524 @default.
• W1998959547 hasAuthorship W1998959547A5058466227 @default.
• W1998959547 hasAuthorship W1998959547A5059691183 @default.
• W1998959547 hasAuthorship W1998959547A5060968872 @default.
• W1998959547 hasAuthorship W1998959547A5087456386 @default.
• W1998959547 hasConcept C144464004 @default.
• W1998959547 hasConcept C159654299 @default.
• W1998959547 hasConcept C170493617 @default.
• W1998959547 hasConcept C178790620 @default.
• W1998959547 hasConcept C17991360 @default.
• W1998959547 hasConcept C185592680 @default.
• W1998959547 hasConcept C203014093 @default.
• W1998959547 hasConcept C2776070231 @default.
• W1998959547 hasConcept C2776330855 @default.
• W1998959547 hasConcept C2778384902 @default.
• W1998959547 hasConcept C2778513237 @default.
• W1998959547 hasConcept C2778754761 @default.
• W1998959547 hasConcept C2778918659 @default.
• W1998959547 hasConcept C2781170229 @default.
• W1998959547 hasConcept C41625074 @default.
• W1998959547 hasConcept C519581460 @default.
• W1998959547 hasConcept C542903549 @default.
• W1998959547 hasConcept C55493867 @default.
• W1998959547 hasConcept C86803240 @default.
• W1998959547 hasConcept C98274493 @default.
• W1998959547 hasConceptScore W1998959547C144464004 @default.
• W1998959547 hasConceptScore W1998959547C159654299 @default.
• W1998959547 hasConceptScore W1998959547C170493617 @default.
• W1998959547 hasConceptScore W1998959547C178790620 @default.
• W1998959547 hasConceptScore W1998959547C17991360 @default.
• W1998959547 hasConceptScore W1998959547C185592680 @default.
• W1998959547 hasConceptScore W1998959547C203014093 @default.
• W1998959547 hasConceptScore W1998959547C2776070231 @default.
• W1998959547 hasConceptScore W1998959547C2776330855 @default.
• W1998959547 hasConceptScore W1998959547C2778384902 @default.
• W1998959547 hasConceptScore W1998959547C2778513237 @default.
• W1998959547 hasConceptScore W1998959547C2778754761 @default.
• W1998959547 hasConceptScore W1998959547C2778918659 @default.
• W1998959547 hasConceptScore W1998959547C2781170229 @default.
• W1998959547 hasConceptScore W1998959547C41625074 @default.
• W1998959547 hasConceptScore W1998959547C519581460 @default.
• W1998959547 hasConceptScore W1998959547C542903549 @default.
• W1998959547 hasConceptScore W1998959547C55493867 @default.
• W1998959547 hasConceptScore W1998959547C86803240 @default.
• W1998959547 hasConceptScore W1998959547C98274493 @default.
• W1998959547 hasIssue "2" @default.
• W1998959547 hasLocation W19989595471 @default.
• W1998959547 hasLocation W19989595472 @default.
• W1998959547 hasOpenAccess W1998959547 @default.
• W1998959547 hasPrimaryLocation W19989595471 @default.
• W1998959547 hasRelatedWork W117947395 @default.
• W1998959547 hasRelatedWork W1214608791 @default.
• W1998959547 hasRelatedWork W1518906031 @default.
• W1998959547 hasRelatedWork W1953875876 @default.
• W1998959547 hasRelatedWork W1986459824 @default.

• next