FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998965120> ?p ?o ?g. }

• W1998965120 endingPage "211" @default.
• W1998965120 startingPage "204" @default.
• W1998965120 abstract "Vascular endothelial growth factor (VEGF) signalling plays a key role in tumour angiogenesis. Cediranib (AZD2171) is a small-molecule VEGF signalling inhibitor with potent activity against all three VEGF receptors. In this phase I, open-label, parallel-group study, adults with advanced solid tumours received a single 45 mg dose of cediranib, followed by 30 mg continuous once-daily oral dosing for 21 days after a 7-day washout period (clinicaltrials.gov identifier NCT00621725). The primary objective was to compare the single-dose pharmacokinetics (PK) of cediranib in patients with different levels of hepatic impairment classified according to the bilirubin level. Safety, tolerability, multiple-dose PK and PK stratified according to the Child–Pugh criteria were also assessed. Thirty patients received cediranib: 18 with normal–mild hepatic impairment and 12 with moderate hepatic impairment. Single-dose PK parameters were similar between the group with normal–mild hepatic impairment and the group with moderate hepatic impairment [ratio of geometric least square means: area under the curve (AUC) 1.12, 90% confidence interval (CI) 0.77–1.61; Cmax 0.95, 90% CI 0.69–1.31]. Hepatic impairment did not influence PK results in multiple dosing. After continuous once-daily dosing, the geometric least square means ratio was 0.72 (90% CI 0.51–1.03) for AUCSS and 0.67 (90% CI 0.47–0.94) for CSS,max. Similar results were obtained when patients were classified for hepatic impairment according to the Child–Pugh criteria. There was no clear difference in the incidence or the severity of adverse events between hepatic impairment groups. Moderate hepatic impairment does not appear to affect the PK profile or the tolerability of cediranib. Dose adjustments are not necessary in this patient population." @default.
• W1998965120 created "2016-06-24" @default.
• W1998965120 creator A5032541182 @default.
• W1998965120 creator A5046503436 @default.
• W1998965120 creator A5048667036 @default.
• W1998965120 creator A5062735715 @default.
• W1998965120 creator A5071757700 @default.
• W1998965120 creator A5077199450 @default.
• W1998965120 date "2013-02-01" @default.
• W1998965120 modified "2023-09-22" @default.
• W1998965120 title "Pharmacokinetics and tolerability of cediranib, a potent VEGF signalling inhibitor, in cancer patients with hepatic impairment" @default.
• W1998965120 cites W1857440086 @default.
• W1998965120 cites W1862871670 @default.
• W1998965120 cites W1982246723 @default.
• W1998965120 cites W2005564013 @default.
• W1998965120 cites W2072270462 @default.
• W1998965120 cites W2073045469 @default.
• W1998965120 cites W2077621121 @default.
• W1998965120 cites W2096415778 @default.
• W1998965120 cites W2097373408 @default.
• W1998965120 cites W2107919129 @default.
• W1998965120 cites W2114440767 @default.
• W1998965120 cites W2137758263 @default.
• W1998965120 cites W2154056804 @default.
• W1998965120 cites W2165630767 @default.
• W1998965120 cites W2240669576 @default.
• W1998965120 doi "https://doi.org/10.1097/cad.0b013e32835bd1d2" @default.
• W1998965120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23197081" @default.
• W1998965120 hasPublicationYear "2013" @default.
• W1998965120 type Work @default.
• W1998965120 sameAs 1998965120 @default.
• W1998965120 citedByCount "6" @default.
• W1998965120 countsByYear W19989651202016 @default.
• W1998965120 countsByYear W19989651202017 @default.
• W1998965120 countsByYear W19989651202018 @default.
• W1998965120 crossrefType "journal-article" @default.
• W1998965120 hasAuthorship W1998965120A5032541182 @default.
• W1998965120 hasAuthorship W1998965120A5046503436 @default.
• W1998965120 hasAuthorship W1998965120A5048667036 @default.
• W1998965120 hasAuthorship W1998965120A5062735715 @default.
• W1998965120 hasAuthorship W1998965120A5071757700 @default.
• W1998965120 hasAuthorship W1998965120A5077199450 @default.
• W1998965120 hasConcept C112705442 @default.
• W1998965120 hasConcept C126322002 @default.
• W1998965120 hasConcept C126894567 @default.
• W1998965120 hasConcept C197934379 @default.
• W1998965120 hasConcept C22979827 @default.
• W1998965120 hasConcept C2777288759 @default.
• W1998965120 hasConcept C2778375690 @default.
• W1998965120 hasConcept C71924100 @default.
• W1998965120 hasConcept C90924648 @default.
• W1998965120 hasConcept C98274493 @default.
• W1998965120 hasConceptScore W1998965120C112705442 @default.
• W1998965120 hasConceptScore W1998965120C126322002 @default.
• W1998965120 hasConceptScore W1998965120C126894567 @default.
• W1998965120 hasConceptScore W1998965120C197934379 @default.
• W1998965120 hasConceptScore W1998965120C22979827 @default.
• W1998965120 hasConceptScore W1998965120C2777288759 @default.
• W1998965120 hasConceptScore W1998965120C2778375690 @default.
• W1998965120 hasConceptScore W1998965120C71924100 @default.
• W1998965120 hasConceptScore W1998965120C90924648 @default.
• W1998965120 hasConceptScore W1998965120C98274493 @default.
• W1998965120 hasIssue "2" @default.
• W1998965120 hasLocation W19989651201 @default.
• W1998965120 hasLocation W19989651202 @default.
• W1998965120 hasOpenAccess W1998965120 @default.
• W1998965120 hasPrimaryLocation W19989651201 @default.
• W1998965120 hasRelatedWork W2037651778 @default.
• W1998965120 hasRelatedWork W2051764329 @default.
• W1998965120 hasRelatedWork W2064759457 @default.
• W1998965120 hasRelatedWork W2074207917 @default.
• W1998965120 hasRelatedWork W2094883508 @default.
• W1998965120 hasRelatedWork W2319060667 @default.
• W1998965120 hasRelatedWork W3087516196 @default.
• W1998965120 hasRelatedWork W3151787567 @default.
• W1998965120 hasRelatedWork W3178697376 @default.
• W1998965120 hasRelatedWork W4377093846 @default.
• W1998965120 hasVolume "24" @default.
• W1998965120 isParatext "false" @default.
• W1998965120 isRetracted "false" @default.
• W1998965120 magId "1998965120" @default.
• W1998965120 workType "article" @default.