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• W1998970209 abstract "Objectives To prospectively identify anxiety and depressive symptoms, and their predictors, during the multiple sclerosis (MS) peridiagnostic period. Methods The Hospital Anxiety and Depression Scale (HADS) was administered during diagnostic workup (baseline), and one and six months after diagnosis disclosure, to SIMS-Trial participants (ISRCTN81072971). Results Of 197 screened patients, 120 (61%) were diagnosed with MS. At baseline, median HADS anxiety (HADS-A) score was 7.0 (interquartile range [IQR] 5.0–9.5), ≥8 (anxiety cut-off) in 43% (95% confidence interval [CI] 34%–52%). Median HADS depression (HADS-D) was 3.0 (IQR 1.0–5.0), ≥8 (depression cut-off) in 11% (95% CI 5%–16%). Independent predictors of anxiety were female sex (odds ratio [OR] 2.8, 95% CI 1.1–7.2) and HADS-D score (OR 20.8, 95% CI 2.5–175.5). The only predictor of depressive symptoms was HADS-A score (OR 20.0, 95% CI 2.8–260.9). Anxiety symptoms had decreased slightly but significantly (p<0.001) at six months. Depressive symptoms remained low. Conclusions Anxiety was prominent in the period surrounding MS diagnosis disclosure, particularly in women. A slight but significant reduction occurred six months after diagnosis disclosure. Depressive symptoms were less common and stable over time. In addition to sex, depressive symptoms were the only variable independently associated with anxiety." @default.
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• W1998970209 date "2011-08-01" @default.
• W1998970209 modified "2023-10-18" @default.
• W1998970209 title "Anxiety and depression in multiple sclerosis patients around diagnosis" @default.
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• W1998970209 doi "https://doi.org/10.1016/j.jns.2011.05.008" @default.
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