Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998973013> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1998973013 endingPage "1890" @default.
- W1998973013 startingPage "1883" @default.
- W1998973013 abstract "Because biological behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and angiogenesis, p21(waf1/cip1) and microvessel density have been targeted as potentially useful tumor markers. We sought to validate the importance of p21(waf1/cip1) and microvessel density and study their interrelationship, analyzing clinical factors, subclassifications, and tumor and stromal markers.We examined p21(waf1/cip1) and other markers in tissue from 61 patients with surgically excised large cell carcinomas. The amount of tumor staining for p21(waf1/cip1) and microvessel density was evaluated by immunohistochemistry and morphometry. The study outcome was survival time until death from recurrent lung cancer.Multivariate Cox model analysis demonstrated that after surgical excision, histologic subtypes were significantly related to survival time (p = 0.02), but quantitative staining of the tumor for p21(waf1/cip1) and microvessel density added prognostic information and these variables were more strongly prognostic than histologic subtype (p = 0.00). Cut points at the median staining of 3.5% and 3.0% for p21(waf1/cip1) and microvessel density, respectively, divided patients into two groups with distinctive survival times. Patients with p21(waf1/cip1) staining of more than 3.5% and microvessel density staining of more than 3.0% had a median survival time of 14 months.Tumor staining for p21(waf1/cip1) and microvessel density in resected large cell carcinomas and certain other types of lung tumors was strongly related to survival. Patients with more than 3.0% staining in their tumors were at high risk of death from lung cancer and may be an appropriate target for prospective studies of adjuvant chemotherapy after surgical resection." @default.
- W1998973013 created "2016-06-24" @default.
- W1998973013 creator A5005652976 @default.
- W1998973013 creator A5012027432 @default.
- W1998973013 creator A5018935556 @default.
- W1998973013 creator A5031009160 @default.
- W1998973013 creator A5041225203 @default.
- W1998973013 creator A5049959068 @default.
- W1998973013 creator A5059076123 @default.
- W1998973013 creator A5062465343 @default.
- W1998973013 creator A5078226544 @default.
- W1998973013 creator A5079456845 @default.
- W1998973013 date "2004-06-01" @default.
- W1998973013 modified "2023-09-27" @default.
- W1998973013 title "Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas" @default.
- W1998973013 cites W1963692923 @default.
- W1998973013 cites W1965419248 @default.
- W1998973013 cites W1988258604 @default.
- W1998973013 cites W1994497611 @default.
- W1998973013 cites W2002873037 @default.
- W1998973013 cites W2042415663 @default.
- W1998973013 cites W2044175751 @default.
- W1998973013 cites W2054852563 @default.
- W1998973013 cites W2061223457 @default.
- W1998973013 cites W2079237537 @default.
- W1998973013 cites W2082651649 @default.
- W1998973013 cites W2090867350 @default.
- W1998973013 cites W2093616760 @default.
- W1998973013 cites W2113257521 @default.
- W1998973013 cites W2134509758 @default.
- W1998973013 cites W2142117154 @default.
- W1998973013 cites W2224818773 @default.
- W1998973013 doi "https://doi.org/10.1016/j.athoracsur.2003.11.047" @default.
- W1998973013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15172229" @default.
- W1998973013 hasPublicationYear "2004" @default.
- W1998973013 type Work @default.
- W1998973013 sameAs 1998973013 @default.
- W1998973013 citedByCount "23" @default.
- W1998973013 countsByYear W19989730132012 @default.
- W1998973013 countsByYear W19989730132013 @default.
- W1998973013 countsByYear W19989730132014 @default.
- W1998973013 countsByYear W19989730132016 @default.
- W1998973013 countsByYear W19989730132017 @default.
- W1998973013 crossrefType "journal-article" @default.
- W1998973013 hasAuthorship W1998973013A5005652976 @default.
- W1998973013 hasAuthorship W1998973013A5012027432 @default.
- W1998973013 hasAuthorship W1998973013A5018935556 @default.
- W1998973013 hasAuthorship W1998973013A5031009160 @default.
- W1998973013 hasAuthorship W1998973013A5041225203 @default.
- W1998973013 hasAuthorship W1998973013A5049959068 @default.
- W1998973013 hasAuthorship W1998973013A5059076123 @default.
- W1998973013 hasAuthorship W1998973013A5062465343 @default.
- W1998973013 hasAuthorship W1998973013A5078226544 @default.
- W1998973013 hasAuthorship W1998973013A5079456845 @default.
- W1998973013 hasConcept C10515644 @default.
- W1998973013 hasConcept C125473707 @default.
- W1998973013 hasConcept C126322002 @default.
- W1998973013 hasConcept C142724271 @default.
- W1998973013 hasConcept C16930146 @default.
- W1998973013 hasConcept C204232928 @default.
- W1998973013 hasConcept C2776256026 @default.
- W1998973013 hasConcept C2776436680 @default.
- W1998973013 hasConcept C2780394083 @default.
- W1998973013 hasConcept C71924100 @default.
- W1998973013 hasConcept C74864618 @default.
- W1998973013 hasConceptScore W1998973013C10515644 @default.
- W1998973013 hasConceptScore W1998973013C125473707 @default.
- W1998973013 hasConceptScore W1998973013C126322002 @default.
- W1998973013 hasConceptScore W1998973013C142724271 @default.
- W1998973013 hasConceptScore W1998973013C16930146 @default.
- W1998973013 hasConceptScore W1998973013C204232928 @default.
- W1998973013 hasConceptScore W1998973013C2776256026 @default.
- W1998973013 hasConceptScore W1998973013C2776436680 @default.
- W1998973013 hasConceptScore W1998973013C2780394083 @default.
- W1998973013 hasConceptScore W1998973013C71924100 @default.
- W1998973013 hasConceptScore W1998973013C74864618 @default.
- W1998973013 hasIssue "6" @default.
- W1998973013 hasLocation W19989730131 @default.
- W1998973013 hasLocation W19989730132 @default.
- W1998973013 hasOpenAccess W1998973013 @default.
- W1998973013 hasPrimaryLocation W19989730131 @default.
- W1998973013 hasRelatedWork W1992481203 @default.
- W1998973013 hasRelatedWork W1993946980 @default.
- W1998973013 hasRelatedWork W2013745628 @default.
- W1998973013 hasRelatedWork W2035464821 @default.
- W1998973013 hasRelatedWork W2040976599 @default.
- W1998973013 hasRelatedWork W2073409722 @default.
- W1998973013 hasRelatedWork W2355053214 @default.
- W1998973013 hasRelatedWork W2413898815 @default.
- W1998973013 hasRelatedWork W2429210815 @default.
- W1998973013 hasRelatedWork W50742768 @default.
- W1998973013 hasVolume "77" @default.
- W1998973013 isParatext "false" @default.
- W1998973013 isRetracted "false" @default.
- W1998973013 magId "1998973013" @default.
- W1998973013 workType "article" @default.