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- W1998976706 abstract "The purpose of this study was to systematically describe the neuropsychiatric side effects of treatment with interferon-α-2b (INF-α) and ribavirin in patients with chronic hepatitis C as well as to compare different instruments used to measure these side effects. Fifty-five patients with chronic hepatitis C were prospectively followed for 24 weeks and assessed with seven neuropsychiatric symptom measures and one quality of life scale. Of 42 patients treated with INF-α and ribavirin, 11 (26%) were receiving psychiatric treatment at baseline. They scored higher on all rating scales at baseline and became more symptomatic during treatment. Of the 31 patients (74%) not in psychiatric care at baseline, 15 (48%) required treatment for neuropsychiatric symptoms, and seven (23%) met criteria for major depression during INF-α therapy. The control group of 13 untreated subjects showed little change over the 24-week period. All symptom scales were highly intercorrelated, suggesting that use of one is sufficient for monitoring symptoms." @default.
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- W1998976706 date "2003-03-01" @default.
- W1998976706 modified "2023-10-16" @default.
- W1998976706 title "A Prospective Study of Neuropsychiatric Symptoms Associated With Interferon-α-2b and Ribavirin Therapy for Patients With Chronic Hepatitis C" @default.
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- W1998976706 doi "https://doi.org/10.1176/appi.psy.44.2.104" @default.
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