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• W1998977136 abstract "The biosynthesis of choline has been studied in the rat with [3-14C]serine, [1,2-14C]-aminoethanol and [14CH3]methionine as precursors. When [14C]aminoethanol was given to intact rats, radioactive choline was isolated from the liver phospholipids, but no radioactive phosphocholine was found in an aqueous liver extract. When [14C]methionine was given, radioactive mono- and dimethylaminoethanol, as well as radioactive choline, were isolated from the liver phospholipids. The mono- and dimethylaminoethanol had much higher turnover rates than had the choline. When [14C]methionine was administered, the incorporation of radioactivity into phospholipid choline, delayed. In vitro experiments showed that choline-labeled lecithin was formed when isolated rat-liver microsomes were incubated with S-adenosylmethionine. When [14C]serine was injected into intact rats, radioactive aminoethanol as well as radioactive choline labeled in both the hydroxyethyl- and in the methyl groups, were isolated. Turnover and specific activity studies showed that phosphoaminoethanol and cytidinediphosphoaminoethanol are unlikely intermediates in the formation of phospholipid aminoethanol from serine. On the basis of these results it is concluded that phosphatidylserine is decarboxylated to phosphatidylaminoethanol and that the latter compounds is methylated to form lecithin. In this reaction all the methyl groups of choline are incorporated by transmethylation from S-adenosylmethionine. The significance of these results is discussed in relation to fat and phospholipid metabolism." @default.
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• W1998977136 date "1960-01-01" @default.
• W1998977136 modified "2023-09-25" @default.
• W1998977136 title "The biosynthesis of choline and its relation to phospholipid metabolism" @default.
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• W1998977136 doi "https://doi.org/10.1016/0006-3002(60)90470-4" @default.
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