FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998981946> ?p ?o ?g. }

• W1998981946 endingPage "359" @default.
• W1998981946 startingPage "347" @default.
• W1998981946 abstract "Abstract Differentiating granule cells develop survival requirements in culture which can be met by treatment with high K + or N‐methyl‐ d ‐aspartate (NMDA) and, according to our recent findings, also with low concentrations of kainic acid (KA, 50 μM). We have now attempted to elucidate the mechanism(s) underlying the trophic effect of KA. KA rescue of cells was completely suppressed by blockers of voltage‐ sensitive calcium channels, such as nifedipine in low concentrations (5×10 −7 M), indicating that the promotion of cell survival is mediated through the activation of these channels by membrane depolarization. Thus the trophic influences of KA and NMDA share a common mechanism, increased Ca 2+ influx (albeit through different routes), a conclusion that is supported by the observation that the effects of these agonists at concentrations causing maximal promotion of cell survival were not additive. Interactive effects involving different classes of excitatory amino acid receptors were revealed by the potentiation of the KA rescue of cells by the NMDA receptor antagonists, 2‐amino 5‐phosphonovalerate (APV) or (+)‐5‐methyl‐10,11‐dihydro‐5 H ‐dibenzo[a,d]cyclohept‐5,10‐imine hydrogen maleate (MK‐801), which on their own failed to promote, but rather reduced cell survival. The potentiation of the KA effect by the competitive NMDA antagonist APV was counteracted by the weak NMDA agonist, quinolinic acid. These observations suggest that KA alone has both trophic and toxic effects, the latter being mediated secondarily through an NMDA‐like glutamate receptor, which is distinct from the conventional NMDA, KA and quisqualate preferring subtypes." @default.
• W1998981946 created "2016-06-24" @default.
• W1998981946 creator A5039449474 @default.
• W1998981946 creator A5049188860 @default.
• W1998981946 creator A5057011976 @default.
• W1998981946 date "1990-01-01" @default.
• W1998981946 modified "2023-10-02" @default.
• W1998981946 title "Interactive effects involving different classes of excitatory amino acid receptors and the survival of cerebellar granule cells in culture" @default.
• W1998981946 cites W1198615125 @default.
• W1998981946 cites W1459608 @default.
• W1998981946 cites W1480873606 @default.
• W1998981946 cites W1489125231 @default.
• W1998981946 cites W1539136314 @default.
• W1998981946 cites W1552405424 @default.
• W1998981946 cites W1562796888 @default.
• W1998981946 cites W1571332234 @default.
• W1998981946 cites W1575445820 @default.
• W1998981946 cites W1576790901 @default.
• W1998981946 cites W1618747402 @default.
• W1998981946 cites W1636078186 @default.
• W1998981946 cites W1912564681 @default.
• W1998981946 cites W1967585087 @default.
• W1998981946 cites W1982884552 @default.
• W1998981946 cites W1987080089 @default.
• W1998981946 cites W1989241549 @default.
• W1998981946 cites W1994689919 @default.
• W1998981946 cites W1994790749 @default.
• W1998981946 cites W2000533408 @default.
• W1998981946 cites W2004850631 @default.
• W1998981946 cites W2007884285 @default.
• W1998981946 cites W2014599626 @default.
• W1998981946 cites W2016759315 @default.
• W1998981946 cites W2023931571 @default.
• W1998981946 cites W2024881866 @default.
• W1998981946 cites W2026660727 @default.
• W1998981946 cites W2027014193 @default.
• W1998981946 cites W2028547793 @default.
• W1998981946 cites W2028758922 @default.
• W1998981946 cites W2031737718 @default.
• W1998981946 cites W2035082471 @default.
• W1998981946 cites W2037335023 @default.
• W1998981946 cites W2042363861 @default.
• W1998981946 cites W2053341391 @default.
• W1998981946 cites W2056018313 @default.
• W1998981946 cites W2058117427 @default.
• W1998981946 cites W2058636883 @default.
• W1998981946 cites W2061496895 @default.
• W1998981946 cites W2061976599 @default.
• W1998981946 cites W2063365220 @default.
• W1998981946 cites W2068789325 @default.
• W1998981946 cites W2085726430 @default.
• W1998981946 cites W2088938537 @default.
• W1998981946 cites W2092797538 @default.
• W1998981946 cites W2097057862 @default.
• W1998981946 cites W2100040827 @default.
• W1998981946 cites W2102131116 @default.
• W1998981946 cites W2115756131 @default.
• W1998981946 cites W2157245781 @default.
• W1998981946 cites W4293247451 @default.
• W1998981946 cites W68470042 @default.
• W1998981946 cites W88461022 @default.
• W1998981946 doi "https://doi.org/10.1016/0736-5748(90)90068-d" @default.
• W1998981946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2174632" @default.
• W1998981946 hasPublicationYear "1990" @default.
• W1998981946 type Work @default.
• W1998981946 sameAs 1998981946 @default.
• W1998981946 citedByCount "48" @default.
• W1998981946 countsByYear W19989819462014 @default.
• W1998981946 countsByYear W19989819462016 @default.
• W1998981946 countsByYear W19989819462017 @default.
• W1998981946 crossrefType "journal-article" @default.
• W1998981946 hasAuthorship W1998981946A5039449474 @default.
• W1998981946 hasAuthorship W1998981946A5049188860 @default.
• W1998981946 hasAuthorship W1998981946A5057011976 @default.
• W1998981946 hasConcept C112592302 @default.
• W1998981946 hasConcept C12554922 @default.
• W1998981946 hasConcept C169760540 @default.
• W1998981946 hasConcept C170493617 @default.
• W1998981946 hasConcept C185592680 @default.
• W1998981946 hasConcept C25274449 @default.
• W1998981946 hasConcept C2776108384 @default.
• W1998981946 hasConcept C2776706248 @default.
• W1998981946 hasConcept C2776885963 @default.
• W1998981946 hasConcept C2777896816 @default.
• W1998981946 hasConcept C2778938600 @default.
• W1998981946 hasConcept C2779652256 @default.
• W1998981946 hasConcept C4141045 @default.
• W1998981946 hasConcept C515207424 @default.
• W1998981946 hasConcept C55493867 @default.
• W1998981946 hasConcept C61174792 @default.
• W1998981946 hasConcept C67018056 @default.
• W1998981946 hasConcept C86803240 @default.
• W1998981946 hasConcept C95444343 @default.
• W1998981946 hasConcept C98274493 @default.
• W1998981946 hasConceptScore W1998981946C112592302 @default.
• W1998981946 hasConceptScore W1998981946C12554922 @default.
• W1998981946 hasConceptScore W1998981946C169760540 @default.
• W1998981946 hasConceptScore W1998981946C170493617 @default.

• next