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• W1998984938 abstract "Purpose of review Cell transplantation is an attractive strategy for the repair of brain neurodegeneration. The scarcity of human fetuses makes finding novel sources of transplantable neuroblasts obligatory. During the last decade, numerous experimental data have highlighted the potential of pigs as donors. Besides the large litter size of pigs, porcine neuroblasts implanted into the lesioned rat brain have been shown to emit long axons that colonize their normal target structure and partially restore the normal architecture of the host brain. However, the functionality of the synapses formed has been poorly investigated. Furthermore, immune phenomena generally provoke the rejection of the xenograft, and this process is difficult to overcome using immunosuppressive treatments compatible with clinical application. Recent findings Recent work has provided new insights into the mechanisms governing the rejection of neural xenografts. In parallel, new immunosuppressive treatments have been designed, which may ultimately lead to transplantation tolerance. Another key issue is the methodological progress that has been made, which paves the way for the genetic modification of pigs. Gene inactivation has been used to generate animals whose cells are less immunogenic when implanted into humans (animals knock out for the galactosyl transferase gene). Transgenesis has also made it possible to introduce, into the donor, human genes involved in the inhibition of some of the host immune defense mechanisms. Summary Such recent progress strongly supports the idea of a new dawn in the field of xenotransplantation, and sheds light on possible new breakthroughs that may lead to its clinical application." @default.
• W1998984938 created "2016-06-24" @default.
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• W1998984938 date "2005-09-01" @default.
• W1998984938 modified "2023-09-26" @default.
• W1998984938 title "Factors affecting neuronal cell xenotransplantation" @default.
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• W1998984938 doi "https://doi.org/10.1097/01.mot.0000174043.67944.6d" @default.
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