FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998984958> ?p ?o ?g. }

• W1998984958 endingPage "18" @default.
• W1998984958 startingPage "6" @default.
• W1998984958 abstract "Ethical dilemmas caused by external events and an interim subset analysis raised concerns about continuing a long-term VA clinical trial comparing early with later zidovudine therapy for symptomatic human immunodeficiency virus (HIV) infection. The first external event was the early termination of other, apparently similar, trials conducted by the AIDS Clinical Trials Group (ACTG) and the announced clear benefits for the zidovudine-treated patients. Interim analysis of the VA trial at this time did not show similar benefits. Subset analyses were performed to explore factors that might explain the different results. These suggested a difference in response to zidovudine in white and minority groups. The Data Monitoring Board and a special advisory panel reviewed these data and concluded that, since the VA results were neutral overall and the subset analyses based on small numbers, the trial should continue. By conference call, the study cochairmen and biostatistician discussed this decision with study personnel without revealing interim results, and study personnel passed the information on to patients at the participating centers. The second event was in March 1990, when the Food and Drug Administration (FDA) approved earlier use of zidovudine, which applied to patients still in the VA trial. Patients were asked to reaffirm their participation by signing a new informed consent that explained the findings reported by the ACTG, the FDA-approved revised recommendations, and the rationale for continuation of the VA trial. The consent form emphasized that continued masked therapy was optional and that unmasked treatment and follow-up would be provided to patients requesting it. Seventy-four percent of the participants chose to continue masked therapy. We conclude that when new external data are announced, informed participation in a long-term clinical trial may require revised consent form and that it is ethical and practical to present this without disclosure of interim study results." @default.
• W1998984958 created "2016-06-24" @default.
• W1998984958 creator A5003110051 @default.
• W1998984958 creator A5021558981 @default.
• W1998984958 creator A5030789303 @default.
• W1998984958 creator A5033900453 @default.
• W1998984958 creator A5043588046 @default.
• W1998984958 creator A5049652855 @default.
• W1998984958 creator A5050785216 @default.
• W1998984958 creator A5053854499 @default.
• W1998984958 creator A5059866301 @default.
• W1998984958 creator A5062598683 @default.
• W1998984958 creator A5064734952 @default.
• W1998984958 creator A5065540263 @default.
• W1998984958 creator A5071811696 @default.
• W1998984958 creator A5083181297 @default.
• W1998984958 date "1993-02-01" @default.
• W1998984958 modified "2023-09-25" @default.
• W1998984958 title "Ethical dilemmas in continuing a zidovudine trial after early termination of similar trials" @default.
• W1998984958 cites W1965791977 @default.
• W1998984958 cites W1978214131 @default.
• W1998984958 cites W1980929657 @default.
• W1998984958 cites W1984043711 @default.
• W1998984958 cites W1991791775 @default.
• W1998984958 cites W2009226722 @default.
• W1998984958 cites W2040573951 @default.
• W1998984958 cites W2059707463 @default.
• W1998984958 cites W2073649109 @default.
• W1998984958 cites W2086462809 @default.
• W1998984958 cites W2093492928 @default.
• W1998984958 cites W2102696271 @default.
• W1998984958 cites W2319972101 @default.
• W1998984958 cites W2333399282 @default.
• W1998984958 cites W4241672864 @default.
• W1998984958 doi "https://doi.org/10.1016/0197-2456(93)90046-g" @default.
• W1998984958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8095008" @default.
• W1998984958 hasPublicationYear "1993" @default.
• W1998984958 type Work @default.
• W1998984958 sameAs 1998984958 @default.
• W1998984958 citedByCount "9" @default.
• W1998984958 countsByYear W19989849582017 @default.
• W1998984958 countsByYear W19989849582019 @default.
• W1998984958 crossrefType "journal-article" @default.
• W1998984958 hasAuthorship W1998984958A5003110051 @default.
• W1998984958 hasAuthorship W1998984958A5021558981 @default.
• W1998984958 hasAuthorship W1998984958A5030789303 @default.
• W1998984958 hasAuthorship W1998984958A5033900453 @default.
• W1998984958 hasAuthorship W1998984958A5043588046 @default.
• W1998984958 hasAuthorship W1998984958A5049652855 @default.
• W1998984958 hasAuthorship W1998984958A5050785216 @default.
• W1998984958 hasAuthorship W1998984958A5053854499 @default.
• W1998984958 hasAuthorship W1998984958A5059866301 @default.
• W1998984958 hasAuthorship W1998984958A5062598683 @default.
• W1998984958 hasAuthorship W1998984958A5064734952 @default.
• W1998984958 hasAuthorship W1998984958A5065540263 @default.
• W1998984958 hasAuthorship W1998984958A5071811696 @default.
• W1998984958 hasAuthorship W1998984958A5083181297 @default.
• W1998984958 hasConcept C126322002 @default.
• W1998984958 hasConcept C142724271 @default.
• W1998984958 hasConcept C15744967 @default.
• W1998984958 hasConcept C17744445 @default.
• W1998984958 hasConcept C199539241 @default.
• W1998984958 hasConcept C204787440 @default.
• W1998984958 hasConcept C2776957806 @default.
• W1998984958 hasConcept C2780216070 @default.
• W1998984958 hasConcept C2780727368 @default.
• W1998984958 hasConcept C3013748606 @default.
• W1998984958 hasConcept C502991105 @default.
• W1998984958 hasConcept C512399662 @default.
• W1998984958 hasConcept C535046627 @default.
• W1998984958 hasConcept C61943457 @default.
• W1998984958 hasConcept C68122502 @default.
• W1998984958 hasConcept C71924100 @default.
• W1998984958 hasConceptScore W1998984958C126322002 @default.
• W1998984958 hasConceptScore W1998984958C142724271 @default.
• W1998984958 hasConceptScore W1998984958C15744967 @default.
• W1998984958 hasConceptScore W1998984958C17744445 @default.
• W1998984958 hasConceptScore W1998984958C199539241 @default.
• W1998984958 hasConceptScore W1998984958C204787440 @default.
• W1998984958 hasConceptScore W1998984958C2776957806 @default.
• W1998984958 hasConceptScore W1998984958C2780216070 @default.
• W1998984958 hasConceptScore W1998984958C2780727368 @default.
• W1998984958 hasConceptScore W1998984958C3013748606 @default.
• W1998984958 hasConceptScore W1998984958C502991105 @default.
• W1998984958 hasConceptScore W1998984958C512399662 @default.
• W1998984958 hasConceptScore W1998984958C535046627 @default.
• W1998984958 hasConceptScore W1998984958C61943457 @default.
• W1998984958 hasConceptScore W1998984958C68122502 @default.
• W1998984958 hasConceptScore W1998984958C71924100 @default.
• W1998984958 hasIssue "1" @default.
• W1998984958 hasLocation W19989849581 @default.
• W1998984958 hasLocation W19989849582 @default.
• W1998984958 hasOpenAccess W1998984958 @default.
• W1998984958 hasPrimaryLocation W19989849581 @default.
• W1998984958 hasRelatedWork W1972502148 @default.
• W1998984958 hasRelatedWork W1974833954 @default.
• W1998984958 hasRelatedWork W1998984958 @default.
• W1998984958 hasRelatedWork W2023402573 @default.

• next