FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998988447> ?p ?o ?g. }

• W1998988447 endingPage "e1000533" @default.
• W1998988447 startingPage "e1000533" @default.
• W1998988447 abstract "Deleterious mutations inevitably emerge in any evolutionary process and are speculated to decisively influence the structure of the genome. Meiosis, which is thought to play a major role in handling mutations on the population level, recombines chromosomes via non-randomly distributed hot spots for meiotic recombination. In many genomes, various types of genetic elements are distributed in patterns that are currently not well understood. In particular, important (essential) genes are arranged in clusters, which often cannot be explained by a functional relationship of the involved genes. Here we show by computer simulation that essential gene (EG) clustering provides a fitness benefit in handling deleterious mutations in sexual populations with variable levels of inbreeding and outbreeding. We find that recessive lethal mutations enforce a selective pressure towards clustered genome architectures. Our simulations correctly predict (i) the evolution of non-random distributions of meiotic crossovers, (ii) the genome-wide anti-correlation of meiotic crossovers and EG clustering, (iii) the evolution of EG enrichment in pericentromeric regions and (iv) the associated absence of meiotic crossovers (cold centromeres). Our results furthermore predict optimal crossover rates for yeast chromosomes, which match the experimentally determined rates. Using a Saccharomyces cerevisiae conditional mutator strain, we show that haploid lethal phenotypes result predominantly from mutation of single loci and generally do not impair mating, which leads to an accumulation of mutational load following meiosis and mating. We hypothesize that purging of deleterious mutations in essential genes constitutes an important factor driving meiotic crossover. Therefore, the increased robustness of populations to deleterious mutations, which arises from clustered genome architectures, may provide a significant selective force shaping crossover distribution. Our analysis reveals a new aspect of the evolution of genome architectures that complements insights about molecular constraints, such as the interference of pericentromeric crossovers with chromosome segregation." @default.
• W1998988447 created "2016-06-24" @default.
• W1998988447 creator A5059107674 @default.
• W1998988447 creator A5075656434 @default.
• W1998988447 date "2009-06-26" @default.
• W1998988447 modified "2023-09-25" @default.
• W1998988447 title "Evolution of Mutational Robustness in the Yeast Genome: A Link to Essential Genes and Meiotic Recombination Hotspots" @default.
• W1998988447 cites W1480665107 @default.
• W1998988447 cites W1550165896 @default.
• W1998988447 cites W1566245339 @default.
• W1998988447 cites W1641544182 @default.
• W1998988447 cites W1663920100 @default.
• W1998988447 cites W1751477646 @default.
• W1998988447 cites W1862994794 @default.
• W1998988447 cites W1904758038 @default.
• W1998988447 cites W1915044809 @default.
• W1998988447 cites W1920935746 @default.
• W1998988447 cites W1933657795 @default.
• W1998988447 cites W1966794959 @default.
• W1998988447 cites W1967579885 @default.
• W1998988447 cites W1970970926 @default.
• W1998988447 cites W1972122284 @default.
• W1998988447 cites W1973843814 @default.
• W1998988447 cites W1974440260 @default.
• W1998988447 cites W1977284533 @default.
• W1998988447 cites W1983153145 @default.
• W1998988447 cites W1984975277 @default.
• W1998988447 cites W1993009001 @default.
• W1998988447 cites W1994328431 @default.
• W1998988447 cites W1996458622 @default.
• W1998988447 cites W2004156548 @default.
• W1998988447 cites W2004227844 @default.
• W1998988447 cites W2004778468 @default.
• W1998988447 cites W2014496483 @default.
• W1998988447 cites W2018401681 @default.
• W1998988447 cites W2019551788 @default.
• W1998988447 cites W2019644042 @default.
• W1998988447 cites W2024289194 @default.
• W1998988447 cites W2026450647 @default.
• W1998988447 cites W2028464019 @default.
• W1998988447 cites W2037878200 @default.
• W1998988447 cites W2043190087 @default.
• W1998988447 cites W2044692345 @default.
• W1998988447 cites W2045312727 @default.
• W1998988447 cites W2049783361 @default.
• W1998988447 cites W2054084132 @default.
• W1998988447 cites W2054755820 @default.
• W1998988447 cites W2062210712 @default.
• W1998988447 cites W2063619692 @default.
• W1998988447 cites W2068119185 @default.
• W1998988447 cites W2070431290 @default.
• W1998988447 cites W2071771941 @default.
• W1998988447 cites W2073228699 @default.
• W1998988447 cites W2081489810 @default.
• W1998988447 cites W2082121926 @default.
• W1998988447 cites W2082601525 @default.
• W1998988447 cites W2087004016 @default.
• W1998988447 cites W2089897141 @default.
• W1998988447 cites W2090293826 @default.
• W1998988447 cites W2092252981 @default.
• W1998988447 cites W2095321122 @default.
• W1998988447 cites W2096160674 @default.
• W1998988447 cites W2099169106 @default.
• W1998988447 cites W2104131863 @default.
• W1998988447 cites W2104280539 @default.
• W1998988447 cites W2104566573 @default.
• W1998988447 cites W2108816867 @default.
• W1998988447 cites W2112635786 @default.
• W1998988447 cites W2113430775 @default.
• W1998988447 cites W2114968751 @default.
• W1998988447 cites W2122298299 @default.
• W1998988447 cites W2122340450 @default.
• W1998988447 cites W2124074193 @default.
• W1998988447 cites W2125407428 @default.
• W1998988447 cites W2126187754 @default.
• W1998988447 cites W2127305172 @default.
• W1998988447 cites W2132691934 @default.
• W1998988447 cites W2133955513 @default.
• W1998988447 cites W2136104310 @default.
• W1998988447 cites W2137148725 @default.
• W1998988447 cites W2137328473 @default.
• W1998988447 cites W2144341530 @default.
• W1998988447 cites W2149641002 @default.
• W1998988447 cites W2151317970 @default.
• W1998988447 cites W2153770183 @default.
• W1998988447 cites W2154046032 @default.
• W1998988447 cites W2159460045 @default.
• W1998988447 cites W2162424238 @default.
• W1998988447 cites W2163776751 @default.
• W1998988447 cites W2166460084 @default.
• W1998988447 cites W2181660414 @default.
• W1998988447 cites W4232203629 @default.
• W1998988447 cites W4235895630 @default.
• W1998988447 doi "https://doi.org/10.1371/journal.pgen.1000533" @default.
• W1998988447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2694357" @default.
• W1998988447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19557188" @default.
• W1998988447 hasPublicationYear "2009" @default.
• W1998988447 type Work @default.

• next