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• W1998996711 abstract "A strong interaction between iron(III) and calf thymus DNA at pH 7.4 was demonstrated in the present study by separation of the complex by column chromatography and by the slow kinetics of iron(III) removal from DNA by disodium-1,2-dihydroxybenzene-3,5-disulfonate (Tiron). An equilibrium constant of 2.1 × 1014 was calculated by measurements of bound iron(III) by flame atomic absorption spectroscopy and assuming a one iron to two nucleotide stoichiometry. Graphic analysis of the interaction however, indicated that DNA has two binding sites for iron(III) characterized by a stoichiometry of one iron to 12 nucleotides and one iron to 2 nucleotides, and association constants of 4.8 × 1012 and 2.3 × 1011, respectively. The DNA-iron(III) complex isolated by column chromatography was shown to catalyze the oxidation of both 2-phenylethylhydrazine and methylhydrazine by spin-trapping experiments with α-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN). By contrast, oxidation of 1,2-dimethylhydrazine was not catalyzed. Catalysis of 2-phenylethylhydrazine oxidation was confirmed by oxygen consumption studies. The results suggest that iron chelated to DNA may be significant in DNA damage induced by oxidizable chemicals." @default.
• W1998996711 created "2016-06-24" @default.
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• W1998996711 date "1991-01-01" @default.
• W1998996711 modified "2023-09-25" @default.
• W1998996711 title "Iron(III) binding in DNA solutions: Complex formation and catalytic activity in the oxidation of hydrazine derivatives" @default.
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• W1998996711 doi "https://doi.org/10.1016/0009-2797(91)90048-c" @default.
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