Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998996946> ?p ?o ?g. }
- W1998996946 endingPage "e1004600" @default.
- W1998996946 startingPage "e1004600" @default.
- W1998996946 abstract "We recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine strategies associated with persistence. Comprehensive analysis of mixed RNA populations from infected tissues revealed that Y. pseudotuberculosis undergoes transcriptional reprogramming with drastic down-regulation of T3SS virulence genes during persistence when the pathogen resides within the cecum. At the persistent stage, the expression pattern in many respects resembles the pattern seen in vitro at 26oC, with for example, up-regulation of flagellar genes and invA. These findings are expected to have impact on future rationales to identify suitable bacterial targets for new antibiotics. Other genes that are up-regulated during persistence are genes involved in anaerobiosis, chemotaxis, and protection against oxidative and acidic stress, which indicates the influence of different environmental cues. We found that the Crp/CsrA/RovA regulatory cascades influence the pattern of bacterial gene expression during persistence. Furthermore, arcA, fnr, frdA, and wrbA play critical roles in persistence. Our findings suggest a model for the life cycle of this enteropathogen with reprogramming from a virulent to an adapted phenotype capable of persisting and spreading by fecal shedding." @default.
- W1998996946 created "2016-06-24" @default.
- W1998996946 creator A5006524527 @default.
- W1998996946 creator A5026541139 @default.
- W1998996946 creator A5027872525 @default.
- W1998996946 creator A5037550701 @default.
- W1998996946 creator A5068384344 @default.
- W1998996946 creator A5078759067 @default.
- W1998996946 creator A5091002552 @default.
- W1998996946 date "2015-01-15" @default.
- W1998996946 modified "2023-10-01" @default.
- W1998996946 title "Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis" @default.
- W1998996946 cites W1556010458 @default.
- W1998996946 cites W1878324752 @default.
- W1998996946 cites W1889684235 @default.
- W1998996946 cites W1963510575 @default.
- W1998996946 cites W1968026360 @default.
- W1998996946 cites W1970786682 @default.
- W1998996946 cites W1975677298 @default.
- W1998996946 cites W1985178609 @default.
- W1998996946 cites W1985884514 @default.
- W1998996946 cites W1986711837 @default.
- W1998996946 cites W1998767819 @default.
- W1998996946 cites W2002077151 @default.
- W1998996946 cites W2005021548 @default.
- W1998996946 cites W2005595694 @default.
- W1998996946 cites W2006756189 @default.
- W1998996946 cites W2021071631 @default.
- W1998996946 cites W2027692104 @default.
- W1998996946 cites W2039808886 @default.
- W1998996946 cites W2041136224 @default.
- W1998996946 cites W2048423383 @default.
- W1998996946 cites W2051407208 @default.
- W1998996946 cites W2052297861 @default.
- W1998996946 cites W2057671789 @default.
- W1998996946 cites W2062022938 @default.
- W1998996946 cites W2071209565 @default.
- W1998996946 cites W2081590523 @default.
- W1998996946 cites W2090487294 @default.
- W1998996946 cites W2095082570 @default.
- W1998996946 cites W2099291451 @default.
- W1998996946 cites W2099364155 @default.
- W1998996946 cites W2100160221 @default.
- W1998996946 cites W2101447465 @default.
- W1998996946 cites W2103800899 @default.
- W1998996946 cites W2106527113 @default.
- W1998996946 cites W2109817270 @default.
- W1998996946 cites W2110383868 @default.
- W1998996946 cites W2111241979 @default.
- W1998996946 cites W2112848373 @default.
- W1998996946 cites W2113977541 @default.
- W1998996946 cites W2119387381 @default.
- W1998996946 cites W2120024428 @default.
- W1998996946 cites W2125924626 @default.
- W1998996946 cites W2125956343 @default.
- W1998996946 cites W2127774782 @default.
- W1998996946 cites W2128658507 @default.
- W1998996946 cites W2129907266 @default.
- W1998996946 cites W2130055485 @default.
- W1998996946 cites W2133166824 @default.
- W1998996946 cites W2134241692 @default.
- W1998996946 cites W2135353569 @default.
- W1998996946 cites W2138419639 @default.
- W1998996946 cites W2148412177 @default.
- W1998996946 cites W2149781820 @default.
- W1998996946 cites W2152885278 @default.
- W1998996946 cites W2153336775 @default.
- W1998996946 cites W2154161436 @default.
- W1998996946 cites W2155184228 @default.
- W1998996946 cites W2158804744 @default.
- W1998996946 cites W2160502767 @default.
- W1998996946 cites W2160697532 @default.
- W1998996946 cites W2171718924 @default.
- W1998996946 cites W2321718094 @default.
- W1998996946 cites W4242955410 @default.
- W1998996946 doi "https://doi.org/10.1371/journal.ppat.1004600" @default.
- W1998996946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4295882" @default.
- W1998996946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25590628" @default.
- W1998996946 hasPublicationYear "2015" @default.
- W1998996946 type Work @default.
- W1998996946 sameAs 1998996946 @default.
- W1998996946 citedByCount "65" @default.
- W1998996946 countsByYear W19989969462015 @default.
- W1998996946 countsByYear W19989969462016 @default.
- W1998996946 countsByYear W19989969462017 @default.
- W1998996946 countsByYear W19989969462018 @default.
- W1998996946 countsByYear W19989969462019 @default.
- W1998996946 countsByYear W19989969462020 @default.
- W1998996946 countsByYear W19989969462021 @default.
- W1998996946 countsByYear W19989969462022 @default.
- W1998996946 countsByYear W19989969462023 @default.
- W1998996946 crossrefType "journal-article" @default.
- W1998996946 hasAuthorship W1998996946A5006524527 @default.
- W1998996946 hasAuthorship W1998996946A5026541139 @default.
- W1998996946 hasAuthorship W1998996946A5027872525 @default.
- W1998996946 hasAuthorship W1998996946A5037550701 @default.
- W1998996946 hasAuthorship W1998996946A5068384344 @default.
- W1998996946 hasAuthorship W1998996946A5078759067 @default.