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• W1999001299 abstract "Initially described in Japan, the autoimmune insulin syndrome is caused by the presence of anti-insulin antibodies in patients who have never received insulin. This syndrome accounts for spontaneous or reactive hypoglycaemia with very high levels of total immuno-reactive insulin. Discordance between the levels of immunoreactive insulin and C peptide indicate the possible presence of anti-insulin antibodies; this can avoid an incorrect diagnosis of insulinoma. These autoimmune hypoglycaemias often present a difficult diagnostic problem in distinguishing them from factitious hypoglycaemia. The course of the autoimmune insulin syndrome is usually favourable, with a spontaneous rapid diminution of the levels of anti-insulin antibodies. The reasons for the appearance of anti-insulin antibodies and the exact mechanisms of the hypoglycaemia remain uncertain. However, the frequent association of the autoimmune insulin syndrome with certain autoimmune diseases suggest a common immune dysfunction. Drugs containing a sulphydryl group have been implicated in the aetiology of this syndrome. Hypoglycémie par auto-anticorps anti-insuline . Initialement décrit au Japon, “I'auto-immune insulin syndrome” est lié à la présence d'anticorps anti-insuline, et ce, chez des patients n'ayant jamais reçu d'insuline. Ce syndrome est à l'origine d'hypoglycémie spontanée ou réactionnelle avec taux très élevés d'insuline totale immuno-réactive. La discordance entre les taux immunoréactives d'insuline et de peptide C doit faire rechercher l'existence d'anticorps anti-insuline, ceci permettant d'éviter de porter à tort le diagnostic d'insulinome. Ces hypoglycomies auto-immunes posent souvent un problème diagnostique difficile avec des hypoglycémies factices. L'évolution du “auto-immune insulin syndrome” est le plus souvent favorable de faron spontanée avec diminution rapide du taux des anticorps anti-insuline. Les raisons de l'apparition des anticorps anti-insuline et les mécanismes exacts des hypoglycémies restent hypothétiques. Cependant, l'association fréquente du “auto-immune insulin syndrome” avec certaines maladies auto-immunes suggèrent une dysrégulation immunitaire commune. Par ailleurs, les médicaments comportant un groupe sulfydril pourraient aussi avoir un rôle dans l'étiologie de ce syndrome ." @default.
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• W1999001299 date "1989-01-01" @default.
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• W1999001299 title "Autoimmune insulin syndrome" @default.
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• W1999001299 doi "https://doi.org/10.1016/0753-3322(89)90036-x" @default.
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